Differential effects of Zincum metallicum on cell models.

CONCLUSIONS: Differing responses and non-linearity were found on macrophages challenged with Zincum metallicum at high dilutions. No changes in melanoma cells were observed. Customised assays using target cells can be useful to investigate high-dilution effects. Other cell types and conditions should be explored. PMID: 28844290 [PubMed - in process]
Source: Homeopathy - Category: Complementary Medicine Authors: Tags: Homeopathy Source Type: research

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AbstractRisk factors for melanoma, the deadliest form of skin cancer, include lifetime sun exposure and a history of sunburns. However, a minority of adolescents report consistent engagement in sun protective behaviors. The few sun protection interventions that have targeted adolescents have had little effect on behavior change, which suggests that a better understanding of the issue, especially from the adolescents ’ perspective, is needed. Although efforts to qualitatively examine adolescent sun protection have been carried out in a handful of countries, no studies to date have focused on U.S. adolescents. We condu...
Source: The Journal of Primary Prevention - Category: Sleep Medicine Source Type: research
Abstract We investigated melanin radicals in paraffin-embedded malignant melanoma (MM) using a surface-type dielectric resonator for X-band electron paramagnetic resonance (EPR) and analyzed the radical species. The surface-type resonator's performance was examined using 5 - 10 μL of 0.1 mM 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPOL) aqueous solution in a 1.0-mm (i.d.) glass capillary as well as 1,1-diphenyl-2-picrylhydrazyl (DPPH) powder. The surface-type detection has approximately two times poorer S/N ratio than commercial insertion-type detection. A sample of the paraffin-embedded MM specimen wa...
Source: Analytical Sciences : the international journal of the Japan Society for Analytical Chemistry - Category: Chemistry Authors: Tags: Anal Sci Source Type: research
Conclusion: Adult NCM patients present a diversity of clinical manifestations. Brain MRI showing diffuse thickening of the leptomeninges with T1 shortening is useful in diagnosing NCM. Heterocellular melanin may be of great value for early diagnosis of NCM in challenging cases.Eur Neurol 2018;80:1 –6
Source: European Neurology - Category: Neurology Source Type: research
A new study into U.S. cancer data finds that checkpoint blockade immunotherapy doubles median overall survival in melanoma patients with brain metastases.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Melanoma / Skin Cancer Source Type: news
Authors: Veronesi G, Ravaioli GM, Lambertini M, Zannetti G, Diodato S, Gardini A, Patrizi A, Fanti S, Dika E PMID: 29998716 [PubMed - as supplied by publisher]
Source: Giornale Italiano di Dermatologia e Venereologia - Category: Dermatology Tags: G Ital Dermatol Venereol Source Type: research
Publication date: Available online 24 December 2015Source: The LancetAuthor(s): Georgi Tchernev, Anastasiya Atanasova Chokoeva
Source: The Lancet - Category: General Medicine Source Type: research
Tumors are complex and heterogeneous but, despite this, they share the ability to proliferate continuously, irrespective of the presence of growth signals, leading to a higher fraction of actively growing and dividing cells compared with normal tissues. For this reason, the cytotoxic antimitotic treatments remain an important clinical tool for tumors. Among these drugs, antitubulin compounds constitute one of the most effective anticancer chemotherapies; however, they cause dose-limiting side effects. Therefore, it is still necessary to develop compounds with new targets and new mechanisms of action to reduce side effects ...
Source: Anti-Cancer Drugs - Category: Cancer & Oncology Tags: Preclinical Reports Source Type: research
This article is protected by copyright. All rights reserved. PMID: 30005129 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research
Publication date: Available online 12 July 2018Source: CellAuthor(s): Florian Rambow, Aljosja Rogiers, Oskar Marin-Bejar, Sara Aibar, Julia Femel, Michael Dewaele, Panagiotis Karras, Daniel Brown, Young Hwan Chang, Maria Debiec-Rychter, Carmen Adriaens, Enrico Radaelli, Pascal Wolter, Oliver Bechter, Reinhard Dummer, Mitchell Levesque, Adriano Piris, Dennie T. Frederick, Genevieve Boland, Keith T. FlahertySummaryMany patients with advanced cancers achieve dramatic responses to a panoply of therapeutics yet retain minimal residual disease (MRD), which ultimately results in relapse. To gain insights into the biology of MRD, ...
Source: Cell - Category: Cytology Source Type: research
Condition:   Non-Small Cell Bronchopulmonary Carcinoma or Melanoma Intervention:   Radiation: 18FDG PET Sponsor:   Centre Antoine Lacassagne Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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