Differential effects of Zincum metallicum on cell models.

CONCLUSIONS: Differing responses and non-linearity were found on macrophages challenged with Zincum metallicum at high dilutions. No changes in melanoma cells were observed. Customised assays using target cells can be useful to investigate high-dilution effects. Other cell types and conditions should be explored. PMID: 28844290 [PubMed - in process]
Source: Homeopathy - Category: Complementary Medicine Authors: Tags: Homeopathy Source Type: research

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Conclusions: The emitter map distribution of the plaque and the computerized tomography of the patient used in a Monte Carlo simulation allow an accurate determination of the plaque position with respect to the tumor with the potential to reduce the dose to sensitive structures.Ocul Oncol Pathol
Source: Ocular Oncology and Pathology - Category: Opthalmology Source Type: research
In conclusion, lyophilization with trehalose is an effective method for the storage of exosomes for various applications.Graphical abstract
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
ConclusionIn our setting, excluding NMSC, the incidence is 8.8 times greater than estimations for the general population, with a high rate of lung cancer, so we should implement preventive and diagnostic strategies.ResumenIntroducciónLa mayor supervivencia del paciente trasplantado viene acompañada del aumento en la tasa de tumores de novo (TN) que representan la complicación tardía más frecuente. Podemos distinguir entre tumores de piel no melanoma (TPNM), síndrome linfoproliferativo postrasplante (SLPT) y tumores de órgano sólido (TOS). Nuestro objetivo es determina...
Source: Cirugia Espanola - Category: Surgery Source Type: research
Journal of the European Academy of Dermatology and Venereology,Volume 0, Issue ja, -Not available-.
Source: Journal of the European Academy of Dermatology and Venereology - Category: Dermatology Authors: Source Type: research
We report the integration of methylation specific PCR (MSP) to melt curve analysis on giant magnetoresistive (GMR) biosensors to greatly enhance the sensitivity of our DNA hybridization assay for methylation detection. Our GMR sensor is functionalized with synthetic DNA probes that target methylated or unmethylated CpG sites in the MSP amplicon, and measures the difference in melting temperature (Tm) between the two probes (ΔTm), giving an analytical limit of detection down to 0.1% methylated DNA in solution. Additionally, linear regression of ΔTm's for serial dilutions of methylated:unmethylated mixtures allow...
Source: Biosensors and Bioelectronics - Category: Biotechnology Source Type: research
This article informs readers about these developments and addresses the items relevant for treatment of head and neck melanomas in particular. PMID: 30302496 [PubMed - as supplied by publisher]
Source: HNO - Category: ENT & OMF Tags: HNO Source Type: research
Publication date: October 2018Source: Chinese Journal of Natural Medicines, Volume 16, Issue 10Author(s): Rakotomalala Manda Heriniaina, Jing DONG, Praveen Kumar Kalavagunta, Hua-Li WU, Dong-Sheng YAN, Jing SHANGAbstractSeveral chemical compounds can restore pigmentation in vitiligo through mechanisms that vary according to disease etiology. In the present study, we investigated the melanogenic activity of six structurally distinct compounds, namely, scopoletin, kaempferol, chrysin, vitamin D3, piperine, and 6-benzylaminopurine. We determined their effectiveness, toxicity, and mechanism of action for stimulating pigmentati...
Source: Chinese Journal of Natural Medicines - Category: Complementary Medicine Source Type: research
In conclusion, lyophilization with trehalose is an effective method for the storage of exosomes for various applications.Graphical abstract
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
This article reviews the concept of immunotherapy in liver cancer with focus on nivolumab. Expert commentary: Immunotherapy in hepatocellular carcinoma provides a new treatment option for patients in advanced stages besides sorafenib and other newly approved tyrosine kinase inhibitors. More data concerning effectivity and choosing the right patients for immunotherapy is warranted in the future. PMID: 30304963 [PubMed - as supplied by publisher]
Source: Expert Review of Anticancer Therapy - Category: Cancer & Oncology Tags: Expert Rev Anticancer Ther Source Type: research
Publication date: Available online 11 October 2018Source: Seminars in Cancer BiologyAuthor(s): Claudia Matteucci, Emanuela Balestrieri, Ayele Argaw-Denboba, Paola Sinibaldi-VallebonaAbstractCancer incidence and mortality, metastasis, drug resistance and recurrence are still the critical issues of oncological diseases. In this scenario, increasing scientific evidences demonstrate that the activation of human endogenous retroviruses (HERVs) is involved in the aggressiveness of tumors such as melanoma, breast, germ cell, renal, ovarian, liver and haematological cancers. In their dynamic regulation, HERVs have also proved to b...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
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