Adjuvant Peptide Pulsed Dendritic Cell Vaccination in Addition to T Cell Adoptive Immunotherapy for Cytomegalovirus Infection in Allogeneic Hematopoietic Stem Cell Transplant (HSCT) Recipients

Adjuvant CMV peptide DC vaccination in addition to donor-derived CMV peptide specific T cell infusion appears to be feasibleNo immediate adverse reactions were noted on DC vaccination or T cell infusion1 of 4 patients developed grade III acute GVHD post DC vaccination and T cell infusionAll patients who received DC vaccination and CMV specific T cell infusion demonstrated immune reconstitution against CMV

Source: Biology of Blood and Marrow Transplantation - August 29, 2017 Category: Hematology Authors: Chun K.K.Ma, Leighton Clancy, Renee Simms, Jane Burgess, Shivashni Deo, Emily Blyth, Kenneth P. Micklethwaite, David J. Gottlieb Source Type: research