Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen [Microbiology]

Middle East respiratory syndrome coronavirus (MERS-CoV) is a lineage C betacoronavirus that since its emergence in 2012 has caused outbreaks in human populations with case-fatality rates of ∼36%. As in other coronaviruses, the spike (S) glycoprotein of MERS-CoV mediates receptor recognition and membrane fusion and is the primary target of...

Source: Proceedings of the National Academy of Sciences - August 29, 2017 Category: Science Authors: Jesper Pallesen, Nianshuang Wang, Kizzmekia S. Corbett, Daniel Wrapp, Robert N. Kirchdoerfer, Hannah L. Turner, Christopher A. Cottrell, Michelle M. Becker, Lingshu Wang, Wei Shi, Wing-Pui Kong, Erica L. Andres, Arminja N. Kettenbach, Mark R. Denison, Jam Tags: PNAS Plus Source Type: research