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Epidemiology of Estrogen and Dementia in Women with Down Syndrome.

Epidemiology of Estrogen and Dementia in Women with Down Syndrome. Free Radic Biol Med. 2017 Aug 23;: Authors: Schupf N, Lee JH, Pang D, Zigman WB, Tycko B, Krinsky-McHale S, Silverman W Abstract Several lines of investigation have shown a protective role for estrogen in Alzheimer's disease through a number of biological actions. This review examines studies of the role of estrogen-related factors in age at onset and risk for Alzheimer's disease in women with Down syndrome, a population at high risk for early onset of dementia. The studies are consistent in showing that early age at menopause and that low levels of endogenous bioavailable estradiol in postmenopausal women with Down syndrome are associated with earlier age at onset and overall risk for dementia. Polymorphisms in genes associated with estrogen receptor activity and in genes for estrogen biosynthesis affecting endogenous estrogen are related to age at onset and cumulative incidence of dementia, and may serve as biomarkers of risk. To date, no clinical trials of estrogen or hormone replacement therapy (ERT/HRT) have been published for women with Down syndrome. While findings from clinical trials of ERT or HRT for dementia have been generally been negative among women in the neurotypical population, the short interval between menopause and onset of cognitive decline, together with a more positive balance between potential benefits and risks, suggests an opportunity to evaluate the efficacy of...
Source: Free Radical Biology and Medicine - Category: Biology Authors: Tags: Free Radic Biol Med Source Type: research

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Conclusion: The findings from this study of applying tactile tests for cognitive examination in individuals with DSL are promising. They indicate that symptoms of dementia can be differentiated from symptoms related to DSL.Dement Geriatr Cogn Disord Extra 2018;8:12 –22
Source: Dementia and Geriatric Cognitive Disorders Extra - Category: Geriatrics Source Type: research
Conclusion: The posterior medial cortices (PMC) are very important areas in episodic memory among patients with mild AD. Verbal memory is more closely related to the both sides of the PMC, while visual memory is more closely related to the right PMC.Dement Geriatr Cogn Disord Extra 2018;8:1 –11
Source: Dementia and Geriatric Cognitive Disorders Extra - Category: Geriatrics Source Type: research
Conclusion: The ePAT is a suitable tool for the assessment of pain in this vulnerable population.Dement Geriatr Cogn Disord 2017;44:256 –267
Source: Dementia and Geriatric Cognitive Disorders - Category: Geriatrics Source Type: research
Conclusions:Our results show that CYP can be effective in patients with SRS with significant improvements in growth velocity and nutritional status before initiation of growth hormone therapy. Further prospective studies are required to confirm these results. Objectives: Nutritional management of children with Silver-Russell syndrome (SRS) is crucial, especially before initiating growth hormone therapy. Since cyproheptadine (CYP) has been reported to be orexigenic, we retrospectively investigated the effects of CYP on changes in weight and height in patients with SRS. Methods: Anthropometric parameters (weight [W], ...
Source: Journal of Pediatric Gastroenterology and Nutrition - Category: Gastroenterology Tags: Original Articles: Nutrition Source Type: research
Acupuncture can be useful for reducing vasomotor symptoms (VMS) in perimenopausal and postmenopausal women, according to results of a systematic review and meta-analysis.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Medscape Today News Source Type: news
"Poor oral health can lead to pneumonia and cardiovascular disease as well as periodontal disease," saidRita A. Jablonski, even though these illnesses are not usually associated with the mouth. Persons with dementia resist care when they feel threatened. In general, these patients cannot care for themselves and need help.byAlzheimer's Reading Room"To my knowledge, we are the only nurses in the country who are looking at ways to improve the mouth care of persons with dementia, especially those who fight and bite during mouth care," said Jablonski. "Our approach is unique because we frame resistive b...
Source: Alzheimer's Reading Room, The - Category: Neurology Authors: Tags: alzheimer's brush teeth Alzheimer's Dementia alzheimers care alzheimers dementia symptoms alzheinmer's symptoms brushing teeth dementia brushing Dental Hygiene and Dementia Source Type: blogs
A new study provides further evidence that exposure to a highly toxic form of amyloid beta injures mitochondria and triggers early events in Alzheimer's.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Alzheimer's / Dementia Source Type: news
AimTo describe health‐related quality of life of Australian children and adolescents with Down syndrome and compare it with norm‐referenced data. MethodA cross‐sectional survey was conducted with parents of 75 children and adolescents (43 males, 32 females) with Down syndrome aged 5 to 18 years (mean age 13y 2mo, SD 4y 8mo). The proxy‐report KIDSCREEN‐27 questionnaire was administered and five dimensions of health‐related quality of life were measured. Data were analysed descriptively and compared with normative data. ResultsTotal group mean scores for psychological well‐being, autonomy and parent relation, a...
Source: Developmental Medicine and Child Neurology - Category: Child Development Authors: Tags: Original Article Source Type: research
In January, 2018, Academic Press published my bookPrecision Medicine and the Reinvention of Human Disease. This book has an excellent " look inside " at itsGoogle book site, which includes the Table of Contents. In addition, I thought it might be helpful to see the topics listed in the Book's index. Note that page numbers followed by f indicate figures, t indicate tables, and ge indicate glossary terms.AAbandonware, 270, 310geAb initio, 34, 48ge, 108geABL (abelson leukemia) gene, 28, 58ge, 95 –97Absidia corymbifera, 218Acanthameoba, 213Acanthosis nigricans, 144geAchondroplasia, 74, 143ge, 354geAcne, 54ge, 1...
Source: Specified Life - Category: Information Technology Tags: index jules berman jules j berman precision medicine Source Type: blogs
DEMENTIA could be prevented by eating more beetroot, it ’s been claimed. Foods high in folate could help to lower the risk of Alzheimer’s disease.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
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