Log in to search using one of your social media accounts:


Epidemiology of Estrogen and Dementia in Women with Down Syndrome.

Epidemiology of Estrogen and Dementia in Women with Down Syndrome. Free Radic Biol Med. 2017 Aug 23;: Authors: Schupf N, Lee JH, Pang D, Zigman WB, Tycko B, Krinsky-McHale S, Silverman W Abstract Several lines of investigation have shown a protective role for estrogen in Alzheimer's disease through a number of biological actions. This review examines studies of the role of estrogen-related factors in age at onset and risk for Alzheimer's disease in women with Down syndrome, a population at high risk for early onset of dementia. The studies are consistent in showing that early age at menopause and that low levels of endogenous bioavailable estradiol in postmenopausal women with Down syndrome are associated with earlier age at onset and overall risk for dementia. Polymorphisms in genes associated with estrogen receptor activity and in genes for estrogen biosynthesis affecting endogenous estrogen are related to age at onset and cumulative incidence of dementia, and may serve as biomarkers of risk. To date, no clinical trials of estrogen or hormone replacement therapy (ERT/HRT) have been published for women with Down syndrome. While findings from clinical trials of ERT or HRT for dementia have been generally been negative among women in the neurotypical population, the short interval between menopause and onset of cognitive decline, together with a more positive balance between potential benefits and risks, suggests an opportunity to evaluate the efficacy of...
Source: Free Radical Biology and Medicine - Category: Biology Authors: Tags: Free Radic Biol Med Source Type: research

Related Links:

PEOPLE who make simple mistakes while carrying out everyday tasks at home could be showing early signs of dementia, according to research published today.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Researchers at the University of California, San Francisco, have developed a new test that may be better at predicting Alzheimer's than APOE E4 alone.
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news
We examined longitudinal trajectories and associations of testosterone (T), dihydrotestosterone (DHT), estradiol (E2), luteinising hormone (LH) and sex hormone‐binding globulin (SHBG) in oldest old men. DesignProspective cohort study. ParticipantsWe studied 1,025 community‐dwelling men median age 75.1 years at baseline with 8.6 years follow‐up. MeasurementsBaseline and follow‐up T, DHT and E2 were assayed using mass spectrometry. Physical performance was assessed at follow‐up. Correlations and covariate‐adjusted P‐values were determined. ResultsLongitudinal change in T was ‐2.0%/year, DHT ‐7.2%/year, LH +...
Source: Clinical Endocrinology - Category: Endocrinology Authors: Tags: Original Article Source Type: research
Eighty per cent of care home residents in the UK are living with dementia. The prevalence of faecal incontinence (FI) in care homes is estimated to range from 30% to 50%. There is limited evidence of what is effective in the reduction and management of FI in care homes. To provide a theory-driven explanation of the effectiveness of programmes that aim to improve FI in people with advanced dementia in care homes.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
Dementia with challenging behaviour (CB) causes significant distress for caregivers and the person with dementia. It is associated with breakdown of care at home and disruption in care homes. Challenge Demcare aimed to assist care home staff and mental health practitioners who support families at home to respond effectively to CB. To study the management of CB in care homes (ResCare) and in family care (FamCare). Following a conceptual overview, two systematic reviews and scrutiny of clinical guidelines, we (1) developed and tested a computerised intervention; (2) conducted a cluster randomised trial (CRT) of the interve...
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
I did and much to my surprise my mother answered without hesitation - Saint Monica's.I had this conversation with my mother in 2010. To put this in context, Dotty first attended Saint Monica's in 1922. At the time of the conversation she was 93 years old; and, in the moderate to severe stage of Alzheimer's.To learn more about this episode go to this article -I Had to Remind Myself - My Mom Was Deeply Forgetful- and look for the story about half way down the page.Solutions to challenges facing caregiversByBob DeMarcoAlzheimer's Reading RoomI'm writing this article because I have been asked several times recently -How do you...
Source: Alzheimer's Reading Room, The - Category: Neurology Tags: alzheimers awareness caregiving deeply forgetful don't be afraid lesson learned living with dementia love dementia memory Source Type: blogs
If you've never had a migraine, I have two things to say to you:1) You're damn lucky.2) You can't begin to imagine how awful they are.I had migraines – three times a month, each lasting three days — starting from age 11 and finally ending at menopause.Although my migraines were not nearly as bad as those that afflict many other people, they took a toll on my work, family life and recreation. Atypically, they were not accompanied by nausea or neck pain, nor did I always have to retreat to a dark, soundless room and lie motionless until they abated. But they were not just"bad headaches" &mda...
Source: Psychology of Pain - Category: Anesthesiology Source Type: blogs
I was a cancer expert long before I was a patient: in control, passionate about my work and invulnerable. Yet all of this would change with one phone call. It was a morning like many before. While discussing a complicated case with a colleague, my cell phone began to vibrate. Seeing the familiar number from the university’s radiology department, I knew it would be a “finding of concern.” With a pang of sadness, I pondered which of my patients I would soon be calling with bad news. The voice on the other end of the line sounded cheerful and upbeat. She told me that they had found five little “irregul...
Source: TIME.com: Top Science and Health Stories - Category: Consumer Health News Authors: Tags: Uncategorized Breast Cancer breast cancer diagnosis breast cancer treatment i have breast cancer oncologist oncology TIME Health Breast Cancer what is breast cancer Source Type: news
When the brain struggles to make sense of the world it may be less able to perform other important tasks.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Ears and Hearing Eyes and Eyesight Memory Alzheimer's Disease Brain Elderly Dementia Hearing Aids Source Type: news
(Florida Atlantic University) With disease-modifying treatment trials for Alzheimer's disease (AD) currently unsuccessful and only medications to treat symptoms available, what now? A leading neuroscientist has developed the " Dementia Prevention Initiative, " which abandons generalized ways to research and treat AD. His secret weapon: a novel " N-of-1 design " that tailors medicine down to a single patient. Instead of conducting a conventional trial of 100 people all getting the same treatment, he has switched it around and is conducting 100 single personalized trials.
Source: EurekAlert! - Social and Behavioral Science - Category: International Medicine & Public Health Source Type: news
More News: Alzheimer's | Biology | Brain | Clinical Trials | Dementia | Down's Syndrome | Epidemiology | Estradiol | Genetics | Hormonal Therapy | Hormone Replacement Therapy | Hormones | Men | Menopause | Neurology | Study | Women