Pathway's power to boost, halt tumors may be promising cancer therapy target

(Penn State) A protein, called inositol-requiring enzyme 1 -- IRE1 -- may serve as a key driver in a series of molecular interactions that can both promote and, paradoxically, inhibit tumors in certain types of cancers, such as non-melanoma skin cancers, according to a team of molecular biologists. They add that this pathway's dual power may make it a tempting target for future research on the design of new types of anti-cancer therapeutics.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news

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DISCUSSION: The yearly number of patients with BCC or SCC treated with radiotherapy, does not reflect the increasing incidence of these tumours. Radiotherapy has potential good treatment outcome in terms of local control and toxicity and seem to be predominantly chosen for tumours located in the head-and-neck area. PMID: 30892970 [PubMed - as supplied by publisher]
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
(MedPage Today) -- Combined risk for new cancers except non-melanoma skin cancer with IL-6r inhibitor not significantly different than with TNF inhibitors
Source: MedPage Today Hematology/Oncology - Category: Hematology Source Type: news
SKIN cancer is caused by ultraviolet light damaging the DNA in skin cells. What ’s commonly not known is there are two types of skin cancer - melanoma skin cancer and non-melanoma skin cancer. A doctor has revealed seven symptoms to look out for.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
A review published in  Experimental Dermatology examined the safety and efficacy of nicotinamide in reducing non-melanoma skin cancers.
Source: CancerNetwork - Category: Cancer & Oncology Authors: Source Type: news
Publication date: Available online 8 March 2019Source: Prostaglandins &Other Lipid MediatorsAuthor(s): Ahmed E.M. Elhassanny, Daniel A. Ladin, Eman Soliman, Hussam Albassam, Andrew Morris, Robert Kobet, Kathleen Thayne, Colin Burns, Allison S. Danell, Rukiyah Van DrossAbstractThe combined incidence of melanoma and non-melanoma skin cancer (NMSC) is greater than the incidence of all other malignancies in the US. Previously, we demonstrated that the endocannabinoid, arachidonoyl-ethanolamide (AEA), was a potent inducer of apoptosis in NMSC. The metabolism of AEA to the prostaglandin, PGD2-EA, was a prerequisite for AEA c...
Source: Prostaglandins and Other Lipid Mediators - Category: Lipidology Source Type: research
ConclusionOur findings highlight the need for an urgent adaptation of healthcare systems across LAC by improving training in geriatrics for the oncology workforce, and by including older adults in clinical guidelines, insurance schemes, and cancer prevention policies.
Source: Journal of Geriatric Oncology - Category: Cancer & Oncology Source Type: research
CONCLUSIONS: We demonstrate a case of SCC successfully treated with intralesional 5-FU and topical Trichloroacetic acid. Additionally, the SCC in situ was successfully cleared in two treatment sessions with the lowest cumulative dose of 5-FU reported. Intralesional injections of 5-FU and subsequent topical Trichloroacetic acid may be an effective option for patients with SCC who are not eligible for cutaneous surgery. PMID: 30843746 [PubMed - as supplied by publisher]
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
ada Y Abstract In recent years, the growing interest in the role played by vitamin D in skin disease has given rise to the publication of many studies of the relationship between this vitamin and certain skin conditions. As dermatologists, we need to understand, among other aspects, how vitamin D is synthesized and the main sources in humans, as well as plasma levels and the factors that can modify them. Of particular interest are the latest discoveries about the role of vitamin D in skin diseases such as lupus erythematosus, ichthyosis, atopic dermatitis, hidradenitis suppurativa, acne, alopecia areata, androgene...
Source: Actas Dermo-Sifiliograficas - Category: Dermatology Authors: Tags: Actas Dermosifiliogr Source Type: research
In conclusion, EL treatment would not increase the risks of premalignant skin lesions and skin cancers in patients with vitiligo. Based on our results, EL is likely to be a safe treatment option for patients with localized vitiligo. This article is protected by copyright. All rights reserved. PMID: 30849210 [PubMed - as supplied by publisher]
Source: Pigment Cell and Melanoma Research - Category: Cytology Authors: Tags: Pigment Cell Melanoma Res Source Type: research
Skin cancer can be broadly categorized into melanoma and nonmelanoma skin cancer (NMSC). Squamous cell carcinoma and basal cell carcinoma are the most common subtypes of NMSC. When a patient presents with a skin finding suspect for NMSC, a confirming skin biopsy is performed. On the basis of the biopsy results, patient factors, and clinical characteristics of the cancer, an appropriate form of treatment is selected. Mohs micrographic surgery (or Mohs) is a tissue-sparing surgical approach, utilizing frozen section margin control. Once removal of the NMSC has been assured by Mohs surgery, the resultant skin defect is evalua...
Source: JDNA: Journal of the Dermatology Nurses Association - Category: Dermatology Tags: FEATURE ARTICLES Source Type: research
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