ANCA-Associated Vasculitis: Pathogenesis, Models, and Preclinical Testing

Summary: Our understanding of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis has developed greatly since the discovery of ANCA, directed against neutrophil components, in 1982. Observations in human disease, and increasingly sophisticated studies in vitro and in rodent models in vivo, have allowed a nuanced understanding of many aspects of the immunopathogenesis of disease, including the significance of ANCA as a diagnostic and monitoring tool as well as a mediator of microvascular injury.

Source: Seminars in Nephrology - August 29, 2017 Category: Urology & Nephrology Authors: Holly L. Hutton, Stephen R. Holdsworth, A. Richard Kitching Source Type: research