Striatal synapses, circuits, and Parkinson's disease.

Striatal synapses, circuits, and Parkinson's disease. Curr Opin Neurobiol. 2017 Aug 24;48:9-16 Authors: Zhai S, Tanimura A, Graves SM, Shen W, Surmeier DJ Abstract The striatum is a hub in the basal ganglia circuitry controlling goal directed actions and habits. The loss of its dopaminergic (DAergic) innervation in Parkinson's disease (PD) disrupts the ability of the two principal striatal projection systems to respond appropriately to cortical and thalamic signals, resulting in the hypokinetic features of the disease. New tools to study brain circuitry have led to significant advances in our understanding of striatal circuits and how they adapt in PD models. This short review summarizes some of these recent studies and the gaps that remain to be filled. PMID: 28843800 [PubMed - as supplied by publisher]
Source: Current Opinion in Neurobiology - Category: Neurology Authors: Tags: Curr Opin Neurobiol Source Type: research