Arsenic and Obesity: A Comparison of Urine Dilution Adjustment Methods

Conclusions:
Our findings suggest that arsenic exposure is not associated with obesity, and that urinary creatinine and osmolality may be colliders on the causal pathway from arsenic exposure to obesity, as common descendants of hydration and body composition. In studies of urinary biomarkers and obesity or obesity-related outcomes, alternative metrics such as urinary flow rate or analytic strategies such as covariate-adjusted standardization should be considered. https://doi.org/10.1289/EHP1202

Received: 07 October 2016
Revised: 21 March 2017
Accepted: 30 March 2017
Published: 28 August 2017
Address correspondence to M. Argos, University of Illinois at Chicago, 1603 W. Taylor St., MC 923, Chicago IL 60612 USA. Telephone: [phone]. Email: [e-mail]
The authors declare they have no actual or potential competing financial interests.
Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact [e-mail]. Our staff will work with you to assess and meet your accessibility needs within 3 working days.

Note to readers with disabilities: EHP has provided a 508-conformant table of contents summarizing the Supplemental Material for this article (see below) so readers with...

Source: EHP Research - August 28, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research