Repetitive Unilateral Intra-amygdala Kainic Acid Injection Establishes A Rhesus Monkey Model of Chronic Temporal Lobe Epilepsy.

CONCLUSIONS: Through a modified protocol of unilateral repetitive intra-amygdala KA injection, a rhesus monkey model with high similarity to chronic TLE was developed.
SIGNIFICANCE: Our results indicated that acute convulsive status epilepticus were not necessary for developing a chronic epilepsy condition in rhesus monkey. And after KA injection, animals showed a progressive nature characterized by secondary discharges.
PMID: 28842304 [PubMed - as supplied by publisher]

Source: Brain Research Bulletin - August 22, 2017 Category: Neurology Authors: Chi Y, Wu B, Guan J, Xiao K, Lu Z, Li X, Xu Y, Xue S, Xu Q, Rao J, Guo Y Tags: Brain Res Bull Source Type: research