The physiopathologic role of oxidative stress in skeletal muscle

Publication date: Available online 26 August 2017 Source:Mechanisms of Ageing and Development Author(s): Bianca Maria Scicchitano, Laura Pelosi, Gigliola Sica, Antonio Musarò Muscle senescence is a complex mechanism that is usually associated with a decrease in mass, strength and velocity of contraction. This state, known as sarcopenia, is a multifactorial process and it may be the consequence of several events, including accumulation of oxidative stress. The role of oxidative stress in the physiopathology of skeletal muscle is quite complex. Transiently increased levels of oxidative stress might reflect a potentially health promoting process, while an uncontrolled accumulation might have pathological implication. The physiopathological role of oxidative stress on skeletal muscle, its involvement in aging-induced sarcopenia, and potential countermeasures will be discussed.

Source: Mechanisms of Ageing and Development - August 26, 2017 Category: Geriatrics Source Type: research