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Ex-miner with a double lung transplant

Nine years of working in coal mines destroyed Will Goddard's lungs, but with the help of a specialist clinic in Rotherham he was able to get a double lung transplant.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news

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Extracorporeal life support in lung transplantation has been associated with poor posttransplant outcomes. However, recent advances have resulted in more favorable posttransplant outcomes. The increased use of this technology must be weighed against the risks inherent in its use, especially when complications arising in extracorporeal membrane oxygenation (ECMO) –dependent patients result in loss of transplant candidacy, leaving them with no viable alternative for long-term support. Existing and emerging data support the judicious use of this technology in carefully selected patients at high-volume transplant and ECM...
Source: Clinics in Chest Medicine - Category: Respiratory Medicine Authors: Source Type: research
This article provides an update on these entities as well as pleural and pulmonary vascular disease after allogeneic HSCT.
Source: Clinics in Chest Medicine - Category: Respiratory Medicine Authors: Source Type: research
Noninfectious acute lung injury syndromes are major causes of respiratory failure and early mortality after hematopoietic stem cell transplantation (HSCT). Pulmonary edema and transfusion-related acute lung injuries are important respiratory complications seen after HSCT and in the nontransplant setting. Early transplant-specific causes of lung injury, such as idiopathic pneumonia syndrome, are reviewed. Several complications, such as drug-induced pneumonitis and cryptogenic organizing pneumonia, that occur in both the early and later time periods after HSCT are also briefly discussed. The important role of pretransplant p...
Source: Clinics in Chest Medicine - Category: Respiratory Medicine Authors: Source Type: research
This article is protected by copyright. All rights reserved.
Source: American Journal of Transplantation - Category: Transplant Surgery Authors: Tags: Original Article Source Type: research
Although several types of transfusion-related adverse reactions (TRARs) have been reported, one of the most important involves respiratory features during and after blood transfusion. Transfusion-related acute lung injury (TRALI) and transfusion-associated circulatory overload (TACO) are the most severe adverse events following blood transfusion, whereas transfusion-associated dyspnea  (TAD) is a less severe respiratory distress. However, there exists little evidence of these factors in pediatric populations.
Source: Transfusion and Apheresis Science - Category: Hematology Authors: Tags: Case Report Source Type: research
This article is protected by copyright. All rights reserved.
Source: American Journal of Transplantation - Category: Transplant Surgery Authors: Tags: Editorial Source Type: research
Abstract The risk of cardiac or lung failure after liver transplantation (LT) is significant. In rare cases, the usual intensive care techniques fail to maintain organ oxygenation with a risk of multiorgan dysfunction. Although extracorporeal membrane oxygenation (ECMO) is a difficult and risky procedure, it can be proposed as life‐saving. Four children with either acute pulmonary (three) or cardiac (one) failure after LT, and the criteria that decided the use of ECMO (level of ventilation and results, dosage of inotropic drugs, cardiac ultrasound, blood lactate) were retrospectively reported. These patients, 1–11 ...
Source: Artificial Organs - Category: Transplant Surgery Authors: Tags: Thoughts and Progress Source Type: research
Authors: Qiu S, Lv D Abstract There have been numerous investigations into the immunosuppressive effects of triptolide; however, its inhibitory effects on memory T cells remain to be elucidated. Using a cluster of differentiation (CD)4(+) memory T-cell transfer model, the aim of the present study was to determine the inhibitory effects of triptolide on CD4(+) memory T cell-mediated acute rejection and to determine the potential underlying mechanisms. At 4 weeks after skin transplantation, mouse cervical heart transplantation was performed following the transfer of CD4(+) memory T cells. Mice were divided into two g...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
We report our initial experience with the use of portable ex  vivo lung perfusion (EVLP) with the Organ Care System Lung device for evaluation of DCD lungs.
Source: Transplantation Proceedings - Category: Transplant Surgery Authors: Tags: New Approaches in Transplantation Source Type: research
ConclusionsThe present study indicates that the intraoperative use of ECMO is associated with increased efficacy and safety, regarding short-term outcomes, compared to CPB. Well-designed, randomized studies, comparing ECMO to CPB, are necessary to assess their clinical outcomes further.
Source: General Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
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