Effect of late prophylaxis in hemophilia on joint status: a randomized trial.

CONCLUSIONS: Over 3 years, prophylaxis versus OD in adults with severe hemophilia A and arthropathy led to decreased bleeding, pain, and HRU, better joint health, activity, satisfaction, and HRQoL, but no reduction in structural arthropathy progression, suggesting pre-existing joint arthropathy may be irreversible. This article is protected by copyright. All rights reserved.
PMID: 28836341 [PubMed - as supplied by publisher]

Source: Thrombosis and Haemostasis - August 24, 2017 Category: Hematology Authors: Manco-Johnson MJ, Lundin B, Funk S, Peterfy C, Raunig D, Werk M, Kempton CL, Reding MT, Goranov S, Gercheva L, Rusen L, Uscatescu V, Pierdominici M, Engelen S, Pocoski J, Walker D, Hong W Tags: J Thromb Haemost Source Type: research