Psychosis subgroups differ in intrinsic neural activity but not task-specific processing

Individuals with psychosis often show high levels of intrinsic, or nonspecific, neural activity, but attenuated stimulus-specific activity. Clementz et al. (2016) proposed that one subgroup of psychosis cases has accentuated intrinsic activity (Biotype-2's) and a different subgroup (Biotype-1's) has diminished intrinsic activity, with both groups exhibiting varying degrees of cognitive deficits. This model was studied by assessing neural activity in psychosis probands (N=105) during baseline and a 5second period in preparation for a pro-/anti-saccade task.

Source: Schizophrenia Research - August 24, 2017 Category: Psychiatry Authors: Matthew E. Hudgens-Haney, Lauren E. Ethridge, Jennifer E. McDowell, Sarah K. Keedy, Godfrey D. Pearlson, Carol A. Tamminga, Matcheri S. Keshavan, John A. Sweeney, Brett A. Clementz Source Type: research