Outcome of Second Transplantation Using Umbilical Cord Blood for Graft Failure after Allogeneic Hematopoietic Stem Cell Transplantation for Aplastic Anemia

• Graft failure after transplant remains a serious problem in aplastic anemia.• Second cord blood transplant is an option for graft failure in aplastic anemia.• Fludarabine plus low-dose TBI-based conditioning tend to show better survival.• Mycofenolate mofetil-containing GVHD prophylaxis ma y improve engraftment rate.

http://www.bbmt.org/article/S1083-8791(17)30655-9/fulltext?rss=yes

Source: Biology of Blood and Marrow Transplantation - August 24, 2017 Category: Hematology Authors: Yasushi Onishi, Takehiko Mori, Shinichi Kako, Hideo Koh, Naoyuki Uchida, Tadakazu Kondo, Takeshi Kobayashi, Hiromasa Yabe, Toshihiro Miyamoto, Koji Kato, Ritsuro Suzuki, Shinji Nakao, Hirohito Yamazaki, on behalf of the adult aplastic anemia working group Source Type: research