Impact of Fluid Overload as New Toxicity Category on Hematopoietic Stem-Cell Transplant Outcomes

Fluid overload (FO) is commonly seen during hospitalization for allogeneic hematopoietic stem-cell transplantation (AHSCT). We hypothesized that FO is associated with transplant outcomes and evaluated this complication in two cohorts of patients and graded based on post-transplant weight gain, symptoms, and need for treatment, and was scored in real time by an independent team. The first cohort (study cohort) underwent haploidentical transplantation for hematologic malignancies (N=145) following a melphalan-based conditioning regimen.

Source: Biology of Blood and Marrow Transplantation - August 24, 2017 Category: Hematology Authors: Gabriela Rond ón, Rima M. Saliba, Julianne Chen, Celina Ledesma, Amin M. Alousi, Betul Oran, Chitra M. Hosing, Partow Kebriaei, Issa F. Khouri, Elizabeth J. Shpall, Uday R. Popat, Richard E. Champlin, Stefan O. Ciurea Source Type: research