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Actin protects mammalian eggs against chromosome segregation errors

Chromosome segregation is driven by a spindle that is made of microtubules but is generally thought to be independent of actin. Here, we report an unexpected actin-dependent mechanism that drives the accurate alignment and segregation of chromosomes in mammalian eggs. Prominent actin filaments permeated the microtubule spindle in eggs of several mammalian species, including humans. Disrupting actin in mouse eggs led to significantly increased numbers of misaligned chromosomes as well as lagging chromosomes during meiosis I and II. We found that actin drives accurate chromosome segregation by promoting the formation of functional kinetochore fibers, the microtubule bundles that align and segregate the chromosomes. Thus, actin is essential to prevent chromosome segregation errors in eggs, which are a leading cause of miscarriages, infertility, and Down syndrome.
Source: ScienceNOW - Category: Science Authors: Tags: Cell Biology, Molecular Biology, Online Only r-articles Source Type: news

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Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
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Source: Trials - Category: Research Source Type: clinical trials
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Source: Virology Journal - Category: Virology Authors: Tags: Research Source Type: research
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Source: Guardian Unlimited Science - Category: Science Authors: Tags: Life and style Marriage Family Psychology Science Health & wellbeing Women Source Type: news
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Source: Advances in Urology - Category: Urology & Nephrology Tags: Adv Urol Source Type: research
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Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
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Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
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