Postnatal Germ Cell Development in the Cryptorchid Testis: The Key to Explain Why Early Surgery Decreases the Risk of Malignancy
Conclusion Prepubertal ITGCN was rare and mostly seen in syndromic cryptorchidism. In nonsyndromic cryptorchidism PLAP-positive undifferentiated spermatogonial stem cells persisted in a significant proportion of nontreated undescended testes and they will be especially sensitive to long-lasting abnormally high temperature that may be the single most important cause facilitating the accumulation of mutations during cell replication and the development of ITGCN to be prevented by orchiopexy. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text
Source: European Journal of Pediatric Surgery - Category: Surgery Authors: Thorup, Jorgen Clasen-Linde, Erik Li, Ruili Reinhardt, Susanne Kvist, Kolja Vikraman, Jaya Southwell, Bridget R. Hutson, John M. Cortes, Dina Tags: Original Article Source Type: research
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