G αq/p63RhoGEF interaction in RhoA/Rho kinase signaling: investigation in Gitelman’s syndrome and implications with hypertension

ConclusionsGitelman ’s syndrome normo/hypotension and lack of cardiovascular–renal remodeling are not due to mutations of p63RhoGEF α6–αN linker and Gαq interactions. This opens the way for investigations on different coding and no-coding regions (p63RhoGEF and Gαq promoters) and on altered transcriptional/po st-transcriptional regulation. Clarification of how these biochemical/molecular mechanisms work/interact would provide insights into mechanisms involved in the GS’s Ang II signaling fine tuning, in human physiology/pathophysiology in general and could also identify significant targets for interven tion in the treatments of hypertension.
Source: Journal of Endocrinological Investigation - Category: Endocrinology Source Type: research