Phenolic Glycolipid Facilitates Mycobacterial Escape from Microbicidal Tissue-Resident Macrophages

Cambier et  al. find that activation of the STING pathway in lung-resident microbicidal macrophages by the mycobacterial surface lipid PGL enables bacterial escape by inducing the recruitment of mycobacterium-permissive monocytes via the CCL2-CCR2 chemokine axis. Their findings reveal a relocation strategy th at enables mycobacterial dissemination, and argue for the potential of interventions targeting PGL in the prevention of tuberculosis.

Source: Immunity - August 24, 2017 Category: Allergy & Immunology Authors: C.J. Cambier, Se ónadh M. O’Leary, Mary P. O’Sullivan, Joseph Keane, Lalita Ramakrishnan Tags: Article Source Type: research