A β accumulation causes MVB enlargement and is modelled by dominant negative VPS4A

Alzheimer ’s disease (AD)-linked β-amyloid (Aβ) accumulates in multivesicular bodies (MVBs) with the onset of AD pathogenesis. Alterations in endosomes are among the earliest changes associated with AD but the ...

Source: Molecular Neurodegeneration - August 23, 2017 Category: Neurology Authors: Katarina Will én, James R. Edgar, Takafumi Hasegawa, Nobuyuki Tanaka, Clare E. Futter and Gunnar K. Gouras Tags: Research article Source Type: research