In the world of continual medical research and advancements - that every day allow us to get improved treatments for ailments - I feel very frustrated. No I am not on top of all research that is going on so I am sure there is a lot that I am not aware of. But from a patient's point of view it can get very frustrating.For example, yesterday I read something about how acentury old vaccine for something else is being tested to see if it would work as a vaccine for fibromyalgia. That sounds great. A way to prevent others from getting fibro - which is no fun.Ahem, but where is the cure? Just because they can prevent someone from getting something they still need a cure. A vaccine only reduces one's risk of getting the ailment and not preventing it 100%. Look at how well the Shingles vaccine works? How many people get the vaccine but still get shingles? I don't know the number but I know it exists - like the flu vaccine.So where does this leave us patients with ailments? Frustrated. How long are we supposed to wait for the cure? We have the 40+ year'War on Cancer'and the Cancer Moonshot. And we are still waiting.
Source: Caroline's Breast Cancer Blog - Category: Cancer & Oncology Tags: cancer vaccine fibromyalgia frustration medical research Source Type: blogs

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We present a case where nocardial abscesses of lung and brain were initially suspected as lung cancer with brain metastases. The patient was treated with a combination of surgical resection and antimicrobial therapy with good outcome. PMID: 31969769 [PubMed - in process]
Source: Acta Clinica Croatica - Category: General Medicine Tags: Acta Clin Croat Source Type: research
MEAN PLATELET VOLUME: AN OVERLOOKED HERALD OF MALIGNANT THYROID NODULES. Acta Clin Croat. 2019 Sep;58(3):417-420 Authors: Sit M, Aktas G, Ozer B, Kocak MZ, Erkus E, Erkol H, Yaman S, Savli H Abstract Physicians and surgeons pay much attention to evaluating thyroid nodules due to the malignant potential of these growths. Inflammation has a crucial role in the development of cancer. Increase in the mean platelet volume (MPV) has been described in various inflammatory conditions. Since some of thyroid nodules are malignant, we aimed to compare MPV values between patients with malignant and benign thyroid ...
Source: Acta Clinica Croatica - Category: General Medicine Tags: Acta Clin Croat Source Type: research
Publication date: Available online 23 January 2020Source: LWTAuthor(s): Xin-Yun Wang, Jing XieAbstractAcinetobacter johnsonii and Pseudomonas fluorescens are specific spoilage microorganisms (SSO) of aquatic products, and their metabolites are effective indicators for analyzing these two SSOs. However, the metabolome of a coculture of A. johnsonii and P. fluorescens is still unclear. The aim of this study was to investigate the metabolomic changes in A. johnsonii, P. fluorescens, and their co-culture by screening for metabolic markers. PCA and PLS-DA revealed that A, P, and AP groups were different from each other, indicat...
Source: LWT Food Science and Technology - Category: Food Science Source Type: research
Source: Gut Microbes - Category: Microbiology Authors: Source Type: research
Abstract In mammals, DNA methyltransferases transfer a methyl group from S-adenosylmethionine to the 5 position of cytosine in DNA. The product of this reaction, 5-methylcytosine (5mC), has many roles, particularly in suppressing transposable and repeat elements in DNA. Moreover, in many cellular systems, cell lineage specification is accompanied by DNA demethylation at the promoters of genes expressed at high levels in the differentiated cells. However, since direct cleavage of the C-C bond connecting the methyl group to the 5 position of cytosine is thermodynamically disfavoured, the question of whether DNA meth...
Source: Journal of Biosciences - Category: Biomedical Science Authors: Tags: J Biosci Source Type: research
Abstract The tumor microenvironment is marked by gradients in the level of oxygen and nutrients, with oxygen levels reaching a minimum at the core of the tumor, a condition known as tumor hypoxia. Mediated by members of the HIF family of transcription factors, hypoxia leads to a more aggressive tumor phenotype by transactivation of several genes as well as reprogramming of pre-mRNA splicing. Intragenic DNA methylation, which is known to affect alternative splicing in cancer, could be one of several reasons behind the changes in splicing patterns under hypoxia. Here, we have tried to establish a correlation between...
Source: Journal of Biosciences - Category: Biomedical Science Authors: Tags: J Biosci Source Type: research
Abstract Accumulating evidences indicate the involvement of epigenetic deregulations in cancer. While some epigenetic regulators with aberrant functions in cancer are targeted for improving therapeutic outcome in patients, reinstating the functions of tumor-suppressor-like epigenetic regulators might further potentiate anti-cancer therapies. Epigenetic reader zinc-finger MYND-type-containing 8 (ZMYND8) has been found to be endowed with multiple anti-cancer functions like inhibition of tumor cell migration and proliferation. Here, we report another novel tumor suppressor role of ZMYND8 as an inducer of differentiat...
Source: Journal of Biosciences - Category: Biomedical Science Authors: Tags: J Biosci Source Type: research
In conclusion, the present study paves the way to elucidate the potential anticancer ionic liquids.
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research
Publication date: Available online 23 January 2020Source: Life SciencesAuthor(s): Irshad Ahmad, Muddasarul HodaAbstractResveratrol is an important phenolic phytochemical from the therapeutic perspective. It has therapeutic impacts over wide range of diseases, especially the ones related to oxidative stress. Resveratrol, being primarily a potent anti-oxidant phytochemical, has significant impact against major diseases as inflammatory disorders, diabetes, and cancer. In the current review article, we intend to highlight the molecular aspects of the mechanism of action of resveratrol against major diabetic implications, namel...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: April 2020Source: Biomedical Signal Processing and Control, Volume 58Author(s): Mohamed Esmail Karar, Ahmed Hamdy El-Garawany, Mohamed El-BrawanyAbstractThis paper introduces a new closed loop fuzzy logic controller for regulating intravenous anti-cancer drug delivery, based on intuitionistic fuzzy sets and invasive weed optimization (IWO) algorithm. The developed intuitionistic fuzzy logic controller (IFLC) contributes the following advancements: First, the parameters of IFLC are adaptive and optimally tuned to achieve desired drug concentrations at the tumor site, killing almost all cancer cells at the ...
Source: Biomedical Signal Processing and Control - Category: Biomedical Science Source Type: research
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