Somatic Testing on Gynecological Cancers Improve the Identification of Lynch Syndrome

Conclusions: Somatic analysis is a useful strategy to distinguish sporadic from LS GC. Our data allow the identification of a subset of LS patients otherwise unrecognized on the basis of clinical or family history alone. In addition, our results indicate that some clinicopathological features including age of GC diagnosis; presence of peritumoral lymphocytes; isthmic, endocervical sites, and body mass index value could be useful criteria to select patients for genetic counseling.
Source: International Journal of Gynecological Cancer - Category: Cancer & Oncology Tags: General Source Type: research