Brain imaging of pain sensitization in patients with knee osteoarthritis

Abstract: A relevant aspect in osteoarthritic pain is neural sensitization. This phenomenon involves augmented responsiveness to painful stimulation and may entail a clinically worse prognosis. We used functional magnetic resonance imaging (fMRI) to study pain sensitization in patients with knee osteoarthritis. Sixty patients were recruited and pain sensitization was clinically defined on the basis of regional spreading of pain (spreading sensitization) and increased pain response to repeated stimulation (temporal summation). Functional magnetic resonance imaging testing involved assessing brain responses to both pressure and heat stimulation. Thirty-three patients (55%) showed regional pain spreading (simple sensitization) and 19 patients (32%) showed both regional spreading and temporal summation. Sensitized patients were more commonly women. Direct painful pressure stimulation of the joint (articular interline) robustly activated all of the neural elements typically involved in pain perception, but did not differentiate sensitized and nonsensitized patients. Painful pressure stimulation on the anterior tibial surface (sensitized site) evoked greater activation in sensitized patients in regions typically involved in pain and also beyond these regions, extending to the auditory, visual, and ventral sensorimotor cortices. Painful heat stimulation of the volar forearm did not discriminate the sensitization phenomenon. Results confirm the high prevalence of pain sensitization s...
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research

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(CNN) — Humid, windy days with low pressure make pain worse in those with long-term health conditions, according to new research. People with conditions like arthritis, fibromyalgia, migraine and neuropathic pain are 20% more likely to suffer pain in such weather, reveals a study carried out by scientists from the University of Manchester, UK. “This would mean that, if your chances of a painful day on an average weather day were 5 in 100, they would increase to 6 in 100 on a damp and windy day,” said study author Will Dixon, professor of Digital Epidemiology, in a statement. Relatively high humidity is th...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health Healthwatch Syndicated CBSN Boston CNN Pain Study Source Type: news
Authors: Pincus T, Schmukler J, Castrejon I Abstract A patient history generally provides the most important information in diagnosis and management of patients with most rheumatic diseases, including osteoarthritis (OA). Patient history components can be expressed as quantitative, structured, "scientific" data, rather than "subjective" narrative descriptions, using patient self-report questionnaires. The Western Ontario McMaster (WOMAC) questionnaire is used in all OA clinical trials, and the health assessment questionnaire (HAQ) in all rheumatoid arthritis (RA) clinical trials, as "diseas...
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
Objective The aim of this study was to examine which analgesics are used by patients with osteoarthritis (OA)–related pain and how the analgesics are used in the preceding month. In addition, their beliefs about (pain) medication and the rationale of those declining to use analgesics were explored. Methods An online cross-sectional survey was sent to 1521 patients participating in the panel of the Dutch Arthritis Foundation. Descriptive analyses and logistic regression were used to analyze data. Results Of the 842 participants (56%) with OA that responded, 70% had generalized OA, 26% had concomitant fibromyal...
Source: JCR: Journal of Clinical Rheumatology - Category: Rheumatology Tags: Original Articles Source Type: research
Conditions:   Chronic Pain;   Fibromyalgia;   Osteoarthritis, Knee;   Osteoarthritis, Hip;   Osteoarthritis;   Ankylosing Spondylitis;   Rheumatoid Arthritis;   Chronic Low-back Pain;   Chronic Shoulder Pain Intervention:   Other: No intervention, observational only. Sponsor:   Illinois Institute of Technology Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This study explored the role of central sensitization (CS) pain in patients with various rheumatic diseases using the CS inventory (CSI).MethodsA total of 193 patients of mean age 50.72  ± 9.65 years were included; they were divided into four different groups in terms of their rheumatic diseases. Patients with rheumatoid arthritis (RA), spondyloarthropathy (SpA), osteoarthritis (OA), and fibromyalgia syndrome (FMS) were evaluated in tertiary care rheumatology/pain medicine se ttings. Disease duration and activity, the Bath Ankylosing Spondylitis Disease Activity Index, the Disease Activity Score-2...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
AbstractAimRecently, the revised 2016 version of the 2010/2011 fibromyalgia (FM) criteria was released. No study has yet assessed whether the 2016 criteria perform better than the previous criteria. Therefore, we validated a Korean version of the revised FM criteria and explored whether they were better than the previous criteria in terms of diagnostic accuracy.MethodsWe enrolled 86 FM patients and 89 patients with various rheumatological disorders, including rheumatoid arthritis, systemic lupus erythematosus, osteoarthritis, and myofascial pain syndrome. All patients were invited to complete a questionnaire that included ...
Source: International Journal of Rheumatic Diseases - Category: Rheumatology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Abstract Acupuncture has been increasingly used as an integrative or complementary therapy for pain. It is well-tolerated with little risk of serious adverse effects. Traditional acupuncture and nontraditional techniques, such as electroacupuncture and dry needling, often result in reported pain improvement. Multiple factors may contribute to variability in acupuncture's therapeutic effects, including needling technique, number of needles used, duration of needle retention, acupuncture point specificity, number of treatments, and numerous subjective (psychological) factors. Controlled trials have been published on...
Source: American Family Physician - Category: Primary Care Authors: Tags: Am Fam Physician Source Type: research
You're reading A Physician Letter Essay Sample, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. From: Dr. Abu Salim Idris (Consultant Neurologist at KPJ Tawakkal Hospital/ MMC NO 23250 / nsr 124687/) To: Whom it may concern I Am writing regarding the health of my patient, name: MOHAMED YAHYA RASHEED AL JUMA, Passport NO: VP3153200 (OMAN), D.O.B: 01/07/1991 The above-mentioned patient was born on the 1st day of July 1991 in Oman and a student at the KDU University in Malaysia. The student is set to go back for hi...
Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: Uncategorized Source Type: blogs
The objective of our study was to compare pain and health-related quality of life among patients with knee osteoarthritis (OA), chronic nonspecific low back pain (CNLBP) and fibromyalgia (FM). This cross-sectional study included 87 subjects, who were divided into three groups according to their diagnosis: knee OA (n=29), CNLBP (n=29) and FM (n=29), between March 2013 and March 2014. Pain intensity was measured using the Numeric Pain Rating Scale (NPRS), quality of pain using the McGill Pain Questionnaire (MPQ) and health-related quality of life using the 36-item Short-Form Health Survey (SF-36). Painful body areas were mar...
Source: Reumatismo - Category: Rheumatology Authors: Tags: Reumatismo Source Type: research
AbstractPurpose of ReviewFibromyalgia (FM) is the second most common rheumatologic pain disorder after osteoarthritis with a multisystem presentation. While the treatment of FM in a clinical setting incorporates both pharmacologic and non-pharmacologic modalities, the present investigation reviews evolving literature on cognitive behavioral and complementary medical therapies. The recent medical literature on FM was reviewed between 2012 and 2017 via MEDLINE and the Cochrane Central Registry of Controlled Trials, with an emphasis on randomized controlled trials, meta-analyses, and evidence-based treatment guidelines.Recent...
Source: Current Pain and Headache Reports - Category: Neurology Source Type: research
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