White matter microstructural deficits in 22q11.2 deletion syndrome

Diffusion tensor imaging (DTI) studies in 22q11.2 Deletion Syndrome (22q11DS), a neurogenetic condition associated with psychosis, report brain white matter (WM) microstructure aberrations. Several studies report that WM disruptions in 22q11DS are similar to deficits in idiopathic schizophrenia. Yet, DTI results in 22q11DS are inconsistent. We used DTI to compare WM structure in 22q11DS individuals to healthy controls (HC) and explored WM differences in 22q11DS with (+) and without (-) psychosis spectrum symptoms.

Source: Psychiatry Research: Neuroimaging - August 23, 2017 Category: Psychiatry Authors: David R. Roalf, J. Eric Schmitt, Simon N. Vandekar, Theodore D. Satterthwaite, Russell T. Shinohara, Kosha Ruparel, Mark A. Elliott, Karthik Prabhakaran, Donna M. McDonald-McGinn, Elaine H. Zackai, Ruben C. Gur, Beverly S. Emanuel, Raquel E. Gur Source Type: research