Advanced glycation end products receptor RAGE controls myocardial dysfunction and oxidative stress in high-fat fed mice by sustaining mitochondrial dynamics and autophagy-lysosome pathway.

In conclusion, modulation of RAGE pathway may improve mitochondrial damage and myocardial dysfunction in HFD mice. Attenuation of cardiac oxidative stress and maintenance of healthy mitochondria population ensuring adequate energy supply may be involved in myocardial protection against HFD. PMID: 28826719 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/28826719?dopt=Abstract

Source: Free Radical Biology and Medicine - August 18, 2017 Category: Biology Authors: Yu Y, Wang L, Delguste F, Durand A, Guilbaud A, Rousselin C, Schmidt AM, Tessier F, Boulanger E, Neviere R Tags: Free Radic Biol Med Source Type: research