Alternative Medicine Alone Leads to Lower Cancer Survival

Cancer patients who opt for alternative therapy instead of conventional medicine significantly decrease their chances of survival, according to researchers at Yale School of Medicine. Although the popularity of alternative medicine continues to grow, a recent study published in the Journal of the National Cancer Institute found survival rates significantly reduced for those who use it as first-line therapy. Conventional cancer treatments — chemotherapy, surgery and radiation — still produce a much better chance of survival. Mesothelioma was not included in the study, but the findings are relevant to this rare and aggressive cancer as alternative treatment becomes more commonly used. “A person with cancer who choses alternative medicine is 2.5 times more likely to die than somebody who uses proven methods of treatment,” Dr. Skyler Johnson, Yale School of Medicine radiation oncologist and lead author of the study, told Asbestos.com. “When you choose alternative medicine instead of conventional, it likely will impact survival [in a negative way].” Study Does Not Include Complementary Therapy The study looked at survival rates for breast, lung, prostate and colorectal cancers, including 840 patients diagnosed from 2004-2013 who were listed in the National Cancer Database. It did not include patients who received alternative therapies alongside conventional medicine — as many mesothelioma patients do. These are often become known as compl...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Tags: acupuncture cancer Alternative medicine alternative mesothelioma treatment alternative therapy survival alternative vs conventional medicine breast cancer colon cancer Conventional cancer treatments Dr. David Gorski Dr. Skyler Johnson Source Type: news

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Publication date: Available online 20 October 2018Source: Journal of Molecular Graphics and ModellingAuthor(s): Süleyman Selim Çınaroğlu, Emel TimuçinAbstractReplication Protein A (RPA) mediates DNA Damage Response (DDR) pathways through protein-protein interactions (PPIs). Targeting the PPIs formed between RPA and other DNA Damage Response (DDR) mediators has become an intriguing area of research for cancer drug discovery. A number of studies applied different methods ranging from high throughput screening approaches to fragment-based drug design tools to discover RPA inhibitors. Although these method...
Source: Journal of Molecular Graphics and Modelling - Category: Molecular Biology Source Type: research
Publication date: Available online 21 October 2018Source: Journal of Theoretical BiologyAuthor(s): Claude Gérard, Didier Gonze, Albert GoldbeterAbstractA network of cyclin-dependent kinases (Cdks) regulated by multiple negative and positive feedback loops controls progression in the mammalian cell cycle. We previously proposed a detailed computational model for this network, which consists of four coupled Cdk modules. Both this detailed model and a reduced, skeleton version show that the Cdk network is capable of temporal self-organization in the form of sustained Cdk oscillations, which correspond to the orderly pr...
Source: Journal of Theoretical Biology - Category: Biology Source Type: research
Publication date: Available online 21 October 2018Source: American Journal of Preventive MedicineAuthor(s): Soham Gupta, Alexander P. Cole, Maya Marchese, Ye Wang, Jacqueline M. Speed, Sean A. Fletcher, Junaid Nabi, Sebastian Berg, Stuart R. Lipsitz, Toni K. Choueiri, Steven L. Chang, Adam S. Kibel, Annemarie Uhlig, Quoc-Dien TrinhIntroductionWith improvements in early detection and treatment, a growing proportion of the population now lives with a personal history of a cancer. Although many cancer survivors are in excellent health, the underlying risk factors and side effects of cancer treatment increase the risk of medic...
Source: American Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
Whole-breast radiation therapy can significantly lower the risk of recurrent...Read more on AuntMinnie.comRelated Reading: Can dedicated breast PET identify suspicious lesions? Women still need breast imaging after mastectomy Is radiation therapy warranted for DCIS postlumpectomy? Microbubbles improve breast cancer radiation therapy ASTRO: Short radiation course safe for breast cancer
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
The objective of this study was to investigate canine gliomas for the IDH1 R132H point mutation using immunohistochemistry. Thirty-one formalin-fixed and paraffin wax-embedded canine gliomas were examined for both IDH1 R132H expression and pan-IDH1 (IDH1 wild-type and point mutated IDH1). Glial tumour specimens were recorded to be either positive or negative for expression. Pan-IDH1 expression was identified in all 31 tumours (100%), while the IDH1 R132H point mutation was identified in none of the tumours (0%). Therefore, the IDH1 R132H point mutation was not identified in this population of canine gliomas and may not be ...
Source: Journal of Comparative Pathology - Category: Pathology Source Type: research
Authors: Buchanan T, Mutch D Abstract INTRODUCTION: Although a relatively uncommon disease, the treatment of vulvar cancer has changed considerably over the years and has been under considerable focus due to its past overtreatment and apparent increase in incidence. The purpose of this review is to describe the recommended management of the most commonly encountered vulvar carcinomas based on the most recent available literature. Areas covered: The clinical environment of squamous cell vulvar cancers are illustrated in order to describe the potential pitfalls and limitations of treatment. Then, by examining publish...
Source: Expert Review of Anticancer Therapy - Category: Cancer & Oncology Tags: Expert Rev Anticancer Ther Source Type: research
A larger, weekly dose of radiation therapy has side effects that are comparable...Read more on AuntMinnie.comRelated Reading: Can dedicated breast PET identify suspicious lesions? Women still need breast imaging after mastectomy Is radiation therapy warranted for DCIS postlumpectomy? Microbubbles improve breast cancer radiation therapy ASTRO: Short radiation course safe for breast cancer
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
s P Abstract Besides providing the majority of ATP production in cells, mitochondria are also involved in many other cellular functions and are central for cellular stress signaling. Mitochondrial dysfunction induces not only inherited mitochondrial disorders but also contributes to neurodegenerative diseases, cancer, diabetes, and metabolic syndrome. The HSP60/HSP10 molecular chaperone complex facilitates folding of mitochondrial proteins and is thus an important factor for many mitochondrial functions. To model different degrees of oxidative stress and mitochondrial dysfunction we here describe a HEK293 derived ...
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research
Authors: Clavreul A, Roger E, Pourbaghi-Masouleh M, Lemaire L, Tétaud C, Menei P Abstract Anticancer agents that target both tumor cells and angiogenesis are of potential interest for glioblastoma (GB) therapy. One such agent is sorafenib (SFN), a tyrosine kinase inhibitor. However, poor aqueous solubility and undesirable side effects limit its clinical application, including local treatment. We encapsulated SFN in lipid nanocapsules (LNCs) to overcome these drawbacks. LNCs are nanocarriers formulated according to a solvent-free process, using only components that have received regulatory approval. SFN-LNCs ...
Source: Drug Delivery - Category: Drugs & Pharmacology Tags: Drug Deliv Source Type: research
By Stacy Simon The death rate from cancer in the US has declined steadily over the past 2 decades, according to annual statistics reporting from the American Cancer Society. The cancer death rate for men and women combined fell 25% from its peak in 1991 to 2014, the most recent year for which data are available. This decline translates to more than 2.1 million deaths averted during this time period. “Cancer Statistics, 2017,” published in the American Cancer Society’s journal CA: A Cancer Journal for Clinicians, estimates the numbers of new cancer cases and deaths expected in the US this year. The estimat...
Source: American Cancer Society :: News and Features - Category: Cancer & Oncology Tags: General Information Source Type: news
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