Nanocarrier based approaches for targeting breast cancer stem cells.

Nanocarrier based approaches for targeting breast cancer stem cells. Artif Cells Nanomed Biotechnol. 2017 Aug 21;:1-14 Authors: Pindiprolu SKSS, Krishnamurthy PT, Chintamaneni PK, Karri VVSR Abstract Breast cancer stem cells (BCSCs) are heterogeneous subpopulation of tumour initiating cells within breast tumours. They are spared even after chemotherapy and responsible for tumour relapse. Targeting BCSCs is, therefore, necessary to achieve radical cure in breast cancer. Despite the availability of agents targeting BCSCs, their clinical application is limited due to their off-target effects and bioavailability issues. Nanotechnology based drug carriers (nanocarriers) offer various advantages to deliver anti-BCSCs agents specifically to their target sites by overcoming their bioavailability issues. In this review, we describe various strategies for targeting BCSCs using nanocarriers. PMID: 28826237 [PubMed - as supplied by publisher]
Source: Artificial Cells, Nanomedicine and Biotechnology - Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research