Lack of Serological and Molecular Association between Toxoplasma Gondii Exposure and Obesity: A Case-Control Study.

Lack of Serological and Molecular Association between Toxoplasma Gondii Exposure and Obesity: A Case-Control Study. Int J Biomed Sci. 2017 Jun;13(2):74-78 Authors: Alvarado-Esquivel C, Maldonado-Soto E, Sanchez-Anguiano LF, Hernandez-Tinoco J, Ramos-Nevarez A, Cerrillo-Soto SM, Sandoval-Carrilo AA, Salas-Pacheco JM, Antuna-Salcido EI, Estrada-Martinez S, Guido-Arreola CA Abstract The association between T. gondii infection and obesity has been scantly studied. Through an age-, and gender-matched case-control study, we determined the association of T. gondii infection and obesity using serological and molecular methods. Cases included 203 persons with obesity, and controls included 203 persons without obesity. Participants were tested for the presence of anti-Toxoplasma IgG antibodies using an enzyme-linked immunoassay (EIA). IgG seropositive individuals were further tested for the presence of anti-T. gondii IgM antibodies using an EIA, and T. gondii DNA by polymerase chain reaction (PCR). Anti-T. gondii IgG antibodies were found in 16 (7.9%) of the 203 cases and in 18 (8.9%) of the 203 controls (OR=0.87; 95% CI: 0.43-1.77; P=0.72). One (6.3%) of the 16 anti-T. gondii IgG seropositive cases and 6 (33.3%) of the 18 anti-T. gondii IgG seropositive controls were positive for IgM (P=0.09). Mean body mass index (35.5 ± 4.5) in T. gondii seropositive cases was similar (P=0.57) to that (36.1 ± 4.5) found in T. gondii seronegative cases. St...
Source: International Journal of Biomedical Science - Category: Biomedical Science Tags: Int J Biomed Sci Source Type: research