Compound heterozygous CASQ2 mutations and long ‐term course of catecholaminergic polymorphic ventricular tachycardia

ConclusionThis study describes a novel CPVT genotype and further characterizes the effect of a previously reported CASQ2 splice site mutation. The long‐term follow‐up of 23 years since first symptom provides additional insight into the natural history of CASQ2‐associated CPVT. We report a case of CPVT caused by compound homozygous loss‐of‐function mutations in CASQ2, a missense early stop codon and splice site mutation with documented disruption of mRNA processing. Details of a greater than 23‐year follow‐up provides new insights on natural history of this potentially lethal disease.
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: Clinical Report Source Type: research

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AbstractBackgroundDexmedetomidine has been shown to have antiarrhythmic effects by exhibiting sympatholytic properties and activating the vagus nerve in preclinical studies. Results from clinical trials of dexmedetomidine on atrial fibrillation (AF) following adult cardiac surgery are controversial.Materials and methodsWe searched EMBASE, PubMed and Cochrane CENTRAL databases for randomized controlled trials (RCTs) comparing the antiarrhythmic effect of dexmedetomidine versus placebo or other anesthetic drugs in adult patients undergoing cardiac surgery. The primary outcome was the incidence of AF. The secondary outcomes w...
Source: American Journal of Cardiovascular Drugs - Category: Cardiology Source Type: research
ConclusionOur PPCM collective treated with standard therapy for heart failure, dopamine D2 receptor agonists, and anticoagulation displays a high and stable long ‐term recovery rate with low mortality at 5‐year follow‐up. However, long‐term use of cardiovascular medication, persisting orde novo hypertension and arrhythmias were frequent.
Source: European Journal of Heart Failure - Category: Cardiology Authors: Tags: Research Article Source Type: research
Despite significant progress in understanding catecholaminergic polymorphic ventricular tachycardia (CPVT), there are still multiple uncertainties and gaps in our knowledge. Like the dark side of the moon, we cannot see them directly. Unfortunately, clinicians must make diagnostic and therapeutic decisions without solid evidence. Instead of summarising the current state of science and reiterating the guidelines, we review difficulties in understanding the disease mechanism, diagnosis and therapy.
Source: Heart, Lung and Circulation - Category: Cardiology Authors: Tags: Review Source Type: research
Review in-depth clinical information, latest medical news, and guidelines about cardiac arrhythmias, including atrial fibrillation, paroxysmal tachycardia, ventricular tachycardia, and ventricular fibrillation. Read about diagnostic tests for arrhythmia and arrhythmia management.
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Resource Center Source Type: news
AbstractOne important complication related to takotsubo syndrome (TTS) is adverse rhythm disorders. Our study was conducted to determine the incidence and management of adverse rhythm disorders in TTS and its long-term prognostic impact. We analyzed 906 TTS patients from 9 European centers. Patients were divided into the adverse rhythm disorders group (encompassing ventricular tachycardia, ventricular fibrillation, torsade de pointes, and asystole or complete atrioventricular block) and non-adverse rhythm disorders group. In our study cohort, we identified 67 (7.4%) patients with presence of adverse rhythm disorders. TTS p...
Source: Heart Failure Reviews - Category: Cardiology Source Type: research
Publication date: December 2019Source: Cardiac Electrophysiology Clinics, Volume 11, Issue 4Author(s): Josef Kautzner, Petr Peichl
Source: Cardiac Electrophysiology Clinics - Category: Cardiology Source Type: research
Publication date: December 2019Source: Cardiac Electrophysiology Clinics, Volume 11, Issue 4Author(s): Yuhong Wang, Lilei Yu, Sunny S. Po
Source: Cardiac Electrophysiology Clinics - Category: Cardiology Source Type: research
ConclusionOur findings suggest that LI is a sensitive parameter to guide RFC ‐ablation in patients with VT. LI indicates differences of tissue characteristics and generally is higher in patients with non‐ischemic cardiomyopathy. Hence, the etiology of the underlying cardiomyopathy needs to be considered when adopting LI for monitoring catheter ablation of VT.This article is protected by copyright. All rights reserved.
Source: Journal of Cardiovascular Electrophysiology - Category: Cardiology Authors: Tags: ORIGINAL ‐ CLINICAL Source Type: research
ConclusionCatheter ablation is an effective treatment for idiopathic VT in children. The acute and long ‐term success rates of catheter ablation for idiopathic VT in pediatric patients with normal heart structure are satisfying.This article is protected by copyright. All rights reserved
Source: Pacing and Clinical Electrophysiology : PACE - Category: Cardiology Authors: Tags: ELECTROPHYSIOLOGY Source Type: research
ConclusionConcomitant use of stimulants and quinolone was associated with an increased hazard of cardiac symptoms in comparison to concomitant use of stimulants and amoxicillin or azithromycin, but there was no apparent difference in cardiac arrhythmias.
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - Category: Drugs & Pharmacology Authors: Tags: Original Research Article Source Type: research
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