Lymphatic system and gut microbiota affect immunopathology of neuroinflammatory diseases, including multiple sclerosis, neuromyelitis optica and Alzheimer's disease
During infection, increased lymphatic flow limits edema and prevents tissue dendritic cell retention, while lymphostasis can lead to chronic inflammation. Helicobacter pylori is associated with not only gastritis but also extra‐intestinal diseases, including neuromyelitis optica (NMO) and Alzheimer's disease, while H. pylori and another bad bacterium Clostridium perfringens type A have been proposed to be protective against multiple sclerosis (MS). The above discrepancy on the roles of microbiota can be attributed to several conflicting factors, such as oversimplification, methodology, and taxonomy, which are summarized as “10 pitfalls of microbiota studies.”
Source: Clinical and Experimental Neuroimmunology - Category: Neurology Authors: Ikuo Tsunoda Tags: Editorial Source Type: research
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