Tuberculosis/cryptococcosis co-infection in China between 1965 and 2016

Tuberculosis/cryptococcosis co-infection in China between 1965 and 2016 Emerging Microbes &Infections 6, e73 (August 2017). doi:10.1038/emi.2017.61 Authors: Wenjie Fang, Lei Zhang, Jia Liu, David W Denning, Ferry Hagen, Weiwei Jiang, Nan Hong, Shuwen Deng, Xia Lei, Danqi Deng, Wanqing Liao, Jianping Xu, Teun Boekhout, Min Chen &Weihua Pan
Source: Emerging Microbes and Infections - Category: Infectious Diseases Authors: Tags: China co-infection cryptococcosis tuberculosis Source Type: research

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ConclusionsThe diagnosis and management of IRIS in the lung in non-HIV patients should be investigated further, especially in the era of anti-TNF treatment.
Source: Respiratory Investigation - Category: Respiratory Medicine Source Type: research
Purpose of review Describe the range of infectious causes of ocular motor neuropathies, from common presentations to unusual manifestations of diseases less frequently seen in the developed world. Provide information on recent developments in diagnostic testing for pathogens that may cause ocular motor neuropathies. Recent findings Antigen detection in serum or CSF has improved the diagnosis of cryptococcal disease. Cartridge PCR testing for tuberculosis has increased diagnostic accuracy, though tuberculous meningitis remains difficult to diagnose. Rapid, multiplex PCR and unbiased sequencing allow for diagnosis of a ...
Source: Current Opinion in Ophthalmology - Category: Opthalmology Tags: NEURO-OPHTHALMOLOGY: Edited by Dean M. Cestari Source Type: research
Abstract Chronic hemodialysis (HD) recipients are nearly ten times more prone to fungal infections compared to the general population. However, infections such as cryptococcosis usually affect immunocompromised patients, unusual in otherwise immunocompetent patients. Here, we describe a unique case of cryptococcosis in a human immunodeficiency virus negative end-stage renal disease (ESRD) patient. A 26-year-old female patient, diagnosed with ESRD, on maintenance HD for the past six months, presented with pyrexia of unknown origin associated with cervical lymphadenopathy, biopsy of which showed granulomatous inflam...
Source: Saudi Journal of Kidney Diseases and Transplantation - Category: Urology & Nephrology Authors: Tags: Saudi J Kidney Dis Transpl Source Type: research
Rationale: Cryptococcosis is a significant life-threatening fungal infection in worldwide, mainly reported in immunocompromised patients. Pleural effusion presentation of cryptococcal infection as the only clinical presentation is rarely seen in pulmonary cryptococcosis, which may lead to be misdiagnosed, and the study on this subject will provide further insights. Patient concerns: A 64-year-old man was hospitalized in our department and diagnosed as hepatic B cirrhosis. A computed tomography (CT) of the thorax showed a massive right pleural effusion without pulmonary parenchymal abnormalities. He was started on empi...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Conditions:   HIV Infections;   Tuberculosis;   Candidiasis, Esophageal;   Cryptococcosis;   Leishmaniasis;   Toxoplasmosis Intervention:   Other: CD4 cell count Sponsor:   Singh, Ranjan Kumar, M.D. Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
In this study they also showed PTX3 localized in NETs formed after neutrophil activation (5). Proteomics analysis revealed that PTX3 forms complexes with two anti-microbial proteins [azurocidin (AZU1) and myeloperoxidase (MPO)] associated to NETs (30). More recently, PTX3 localization in NETs has been confirmed, and the colocalization with AZU1 and MPO has been defined more accurately (31). Further investigation will be needed to understand the involvement of PTX3 interaction with AZU1 and MPO in their antibacterial role during NET formation. Regulation of Complement Activation PTX3 interaction with microorganisms is not...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
In conclusion, our findings demonstrate that in the presence of an HIV-1 infection, the cellular distribution of FcγRIIIa is altered and that the functional consequence of FcγRIIIa variant is affected. Importantly, it underscores the need to characterize FcγR expression, cellular distribution and functional consequences of FcγR genetic variants within a specific environment or disease state. Introduction Receptors for the Fc domain of immunoglobulin G (IgG), so called Fc gamma receptors (FcγRs), link the specificity of IgG with potent effector functions of the innate immune system. Fc&ga...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
ConclusionThe introduction of Highly Active Anti Retroviral Therapy (HAART) has lead to a decline in the incidence of HIV related infections and neoplasms. Nevertheless, these are conditions are still seen. Imaging diagnosis relies to the radiological findings coupled with serological and CSF analysis. The radiologist should be aware of the changing epidemiology of HIV complications in correlation with immune status of the patient which helps establish the correct diagnosis and improve management and prognosis.
Source: Journal of Neuroradiology - Category: Radiology Source Type: research
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