Red blood cells release microparticles containing human argonaute 2 and miRNAs to target genes of Plasmodium falciparum

Red blood cells release microparticles containing human argonaute 2 and miRNAs to target genes of Plasmodium falciparum Emerging Microbes &Infections 6, e75 (August 2017). doi:10.1038/emi.2017.63 Authors: Zhensheng Wang, Juemin Xi, Xiao Hao, Weiwei Deng, Juan Liu, Chunyan Wei, Yuhui Gao, Lianhui Zhang &Heng Wang
Source: Emerging Microbes and Infections - Category: Infectious Diseases Authors: Tags: human argonaute 2 malaria microparticle miRNA Plasmodium falciparum Source Type: research

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Not in person, as both are rather historical, but when in Paris, I encountered:Dr Alphonse LaveranandDr Paul GachetDr Laveran has a square named after him, adjacent to the Ecole de Val de Grace, a school of military medicine, where he worked after serving in the army as a physician, and where his father had held the same post.   Paris is good at telling you who a street is named after, so the street sign tells you he was the first French winner of theNobel Prize for Medicine or Physiology.  He won it for identifying both malaria and sleeping sickness as caused by parasites.Dr Gachet has aportrait in the...
Source: Browsing - Category: Databases & Libraries Source Type: blogs
ConclusionThe present study revealed that oral administration of CM extract for 28 days, at dosage up to 1000 mg/kg did not induce toxicological damage in rats. From acute toxicity study, the median lethal dose (LD50) of the extract was estimated to be more than 5000 mg/kg.Graphical abstract
Source: Toxicology Reports - Category: Toxicology Source Type: research
[Radio Dabanga] Haya / Agig -Two people have died, and hundreds of cattle have been struck by a fever - suspected to be a strain of malaria - in Sudan's Red Sea state, local representatives report.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
This study provides strong evidence that following a healthy lifestyle can substantially extend the years a person lives disease-free." Commentary on Recent Evidence for Cognitive Decline to Precede Amyloid Aggregation in Alzheimer's Disease https://www.fightaging.org/archives/2020/01/commentary-on-recent-evidence-for-cognitive-decline-to-precede-amyloid-aggregation-in-alzheimers-disease/ I can't say that I think the data presented in the research noted here merits quite the degree of the attention that it has been given in the popular science press. It is interesting, but not compelling if its role...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
In this study, we investigated the role of GBP2 in virulence and sexual development of P. berghei using gbp2-deleted P. berghei (Δgbp2 parasites). Then, to identify factors affected by gbp2 deletion, we performed a comparative proteomic analysis of the Δgbp2 parasites. We found that GBP2 was not associated with the development of experimental cerebral malaria during infection with P. berghei, but asexual development of the parasite was delayed with deletion of gbp2. However, the development of P. berghei gametocytes was significantly reduced with deletion of gbp2. Comparative proteomic analysis revealed that th...
Source: Parasitology International - Category: Parasitology Source Type: research
CHERYL, best known for being a member of Girls Aloud and for judging talent show competitions such as The Greatest Dancer, was left fighting for her life back in 2010 after contracting malaria.
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Source: Human Vaccines and Immunotherapeutics - Category: Allergy & Immunology Authors: Source Type: research
AbstractPlasmodium falciparum is the cause of malaria and has become resistant to the drugs used to treat the disease. Therefore, the development for novel compounds with antimalarial activity has become urgent. Plant species, such as naphthoquinone-richEleutherine plicata, may provide novel substances that exhibit antimalarial activity and serve as an alternative for the treatment of this disease. From this plant species, ethanol extracts were obtained, fractionated, and the isolated substances eleutherin, and isoleutherin were characterized by nuclear magnetic resonance. There in vitro activity againstPlasmodium falcipar...
Source: Medicinal Chemistry Research - Category: Chemistry Source Type: research
Date: Friday, 01 24, 2020; Speaker: Peter D. Crompton, M.D., M.P.H. , Chief, Malaria Infection Biology and Immunity Unit , Laboratory of Immunogenetics, NIAID ; Building 1; Wilson Hall ; Videocast Event
Source: NIH Calendar of Events - Category: American Health Source Type: events
In this study, we analyzed 677,423 human body temperature measurements from three different cohort populations spanning 157 years of measurement and 197 birth years. We found that men born in the early 19th century had temperatures 0.59°C higher than men today, with a monotonic decrease of -0.03°C per birth decade. Temperature has also decreased in women by -0.32°C since the 1890s with a similar rate of decline (-0.029°C per birth decade). Although one might posit that the differences among cohorts reflect systematic measurement bias due to the varied thermometers and methods used to obtain temperatures, we...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
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