Evaluation of pharmacokinetic model designs for subcutaneous infusion of insulin aspart

AbstractEffective mathematical modelling of continuous subcutaneous infusion pharmacokinetics should aid understanding and control in insulin therapy. Thorough analysis of candidate model performance is important for selecting the appropriate models. Eight candidate models for insulin pharmacokinetics included a range of modelled behaviours, parameters and complexity. The models were compared using clinical data from subjects with type 1 diabetes with continuous subcutaneous insulin infusion. Performance of the models was compared through several analyses: R2 for goodness of fit; the Akaike Information Criterion; a bootstrap analysis for practical identifiability; a simulation exercise for predictability. The simplest model fit poorly to the data (R2 = 0.53), had the highest Akaike score, and worst prediction. Goodness of fit improved with increasing model complexity (R2 = 0.85–0.92) but Akaike scores were similar for these models. Complexity increased practical non-identifiability, where small changes in the dataset caused large variation (CV >  10%) in identified parameters in the most complex models. Best prediction was achieved in a relatively simple model. Some model complexity was necessary to achieve good data fit but further complexity introduced practical non-identifiability and worsened prediction capability. The best model used two linear subcutaneous compartments, an interstitial and plasma compartment, and two identified var...
Source: Journal of Pharmacokinetics and Pharmacodynamics - Category: Drugs & Pharmacology Source Type: research

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Publication date: January–February 2020Source: Revista Clínica Española (English Edition), Volume 220, Issue 1Author(s): J. Ena, R. Gómez-Huelgas
Source: Revista Clinica Espanola - Category: Internal Medicine Source Type: research
Conclusion: The seroprevalence ofH. pylori antibodies was lower compared to most developing countries. Keeping a dog, household size, indoor tap water, fathers ’ occupation and diabetes mellitus type 1 were found to be independent predictors of presence ofH. pylori antibodies.Keywords:Helicobacter Pylori.
Source: African Health Sciences - Category: African Health Source Type: research
AbstractTo examine how self-regulation and social-regulation surrounding type 1 diabetes (T1D) management are coordinated during early emerging adulthood and whether classes of coordination relate to HbA1c and executive functioning (EF). Emerging adult participants (N = 212) with T1D (M age = 18.8 years, SD = .40) completed a 14-day diary to capture components of self-regulation and social-regulation. A mixture multi-level latent coordination model first determined the separate but coordinated factor structure of self- and social-regulation, then de termined the number of dist...
Source: Journal of Behavioral Medicine - Category: Psychiatry Source Type: research
Condition:   Type 1 Diabetes Interventions:   Other: MDI;   Device: AHCL Sponsor:   Medtronic Diabetes Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Diabetes Mellitus, Type 1 Intervention:   Drug: Gan & Lee Insulin Glargine Injection Sponsor:   Gan and Lee Pharmaceuticals, USA Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Type 1 Diabetes Interventions:   Other: MDI;   Device: AHCL Sponsor:   Medtronic Diabetes Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Diabetes Mellitus, Type 1 Intervention:   Drug: Gan & Lee Insulin Glargine Injection Sponsor:   Gan and Lee Pharmaceuticals, USA Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
As the prevalence of type 1 and type 2 diabetes increases and population-level patterns of alcohol and illicit drug use evolve, clinicians will continue to encounter people with diabetes whose substance use is affecting health outcomes. Substance use contr...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
Authors: Qadir KJ, Zangana KO Abstract BACKGROUND: Regular physical activity and exercise is the third management for the child with diabetes mellitus after diet regime and insulin therapy. The aim of the study is to evaluate the effect of swimming on glycemic control for a male adolescent with type 1 diabetes mellitus. OBJECTIVE: The study evaluates the effect of swimming on glycemic control for a male adolescent with type 1 diabetes mellitus. METHODS: The quasi-experimental design was conducted on 40 male adolescents with typ1 diabetes, then divided into two groups; study and control groups. 20 adolescent...
Source: Journal of Sports Medicine and Physical Fitness - Category: Sports Medicine Tags: J Sports Med Phys Fitness Source Type: research
The advent of insulin pump therapy marked an important milestone in diabetes treatment in the past few decades and has become the tipping point for the development of automated insulin delivery systems (AID). Standalone insulin pump systems have evolved over the course of years and have been replaced by modern high-technology insulin pumps with continuous glucose monitor interface allowing real-time insulin dose adjustment to optimize treatment. This review summarizes evidence from AID studies conducted in children with type 1 diabetes and discusses the outlook for future generation AID systems from a pediatric treatment perspective.
Source: Endocrinology and Metabolism Clinics of North America - Category: Endocrinology Authors: Source Type: research
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