Molecular and biological analysis of human hematopoietic stem cells at single-cell resolution

Elucidating the properties and processes regulating primitive hematopoietic cell behavior constitutes a clinically important but still elusive goal. A new challenge in addressing these questions has emerged from experiments in mice that have revealed multiple sources of intrinsically determined heterogeneity in the self renewal potential, lineage competence and proliferation state of these cells. In addition, it is has been shown that these key properties are not coordinately regulated when the cells are stimulated with different external cues.

Source: Experimental Hematology - August 22, 2017 Category: Hematology Authors: Connie Eaves, D.J.H.F. Knapp, C.A. Hammond, A. Hui, M. van Loenhout, D. Pellacani, F. Wang, P.H. Miller, A. Lorzadeh, N. Aghaeepour, M. Moksa, M. Vaninsberghe, G.M. Rabu, P.A. Beer, R.K. Humphries, S. Bendall, G.P. Nolan, C. Hansen, M. Hirst Source Type: research