Cellular hierarchy and molecular mechanisms underlying haematopoietic stem cell development

During embryonic development, adult haematopoietic stem cells (HSCs) emerge preferentially in the ventral domain of the aorta in the aorta –gonad–mesonephros (AGM) region. Using a combination of ex vivo and in vivo approaches, we found that stage-specific reciprocal dorso–ventral inductive interactions and lateral input from the urogenital ridges are required to drive HSC development in the aorta. These inductive interactions in the AGM region are mediated by the interplay between spatially polarized signalling pathways, which are integral parts of the regulatory system involved in the development of HSCs.

Source: Experimental Hematology - August 22, 2017 Category: Hematology Authors: Alexander Medvinsky, Stanislav Rybtsov, Alison McGarvey, Celine Souilhol, Antoniana Batsivari Source Type: research