Enhancer mechanisms governing developmental and regenerative hematopoietic programs

Establishment of the hematopoietic system requires the transcription factor GATA-2, and human GATA-2 mutations cause immunodeficiency, myelodysplastic syndrome, acute myeloid leukemia and vascular/lymphatic dysfunction. GATA-2-regulated enhancers differentially control Gata2 expression in hematopoietic stem/progenitor cells to ensure normal hematopoiesis. The enhancer +9.5 kb downstream of the transcription start site activates Gata2 transcription in endothelium and hematopoietic stem cells (HSCs), and its deletion in mice abrogates HSC generation.

Source: Experimental Hematology - August 22, 2017 Category: Hematology Authors: Emery Bresnick, Kyle Hewitt, Charu Mehta, Kirby Johnson, Daniel Matson, Koichi Katsumura, Xin Gao, Skye McIver, Prithvia Devadas, Alexander Hebert, Joshua Coon, Jin-Soo Kim, Irene Ong, Erik Ranheim, Colin Dewey, Sunduz Keles, Robert Paulson Source Type: research