Emergence of definitive hematopoiesis in Myb-null mouse embryos

In the adult, the proto-oncogene Myb critically regulates both the maintenance of hematopoiesis and the differentiation of several hematopoietic lineages. Myb-null mouse embryos die beginning at embryonic day (E) 15.5 with severe anemia due to the absence of definitive erythropoiesis. These and other data have led to the concept that Myb-null embryos entirely lack hematopoietic stem cells (HSCs) and definitive hematopoiesis. During embryogenesis, the first definitive hematopoietic potential arises prior to HSCs as a wave of erythro-myeloid progenitors (EMP), which seed the liver and generate the first definitive erythrocytes.

Source: Experimental Hematology - August 22, 2017 Category: Hematology Authors: James Palis, Jenna Frame, Emanuele Azzoni, Anne Koniski, Jacquelyn Lillis, Marella de Bruijn, Kathleen McGrath Source Type: research