Roundabout ways to lineage commitment

The lineage potential, heterogeneity, and relationships of hematopoietic stem and progenitor cells (HSPCs) are currently unclear. To gain new insights into these questions, we performed quantitative analyses of mature cell production by transplanted HSPCs. Assessment of the absolute numbers of mature cell types produced by each progenitor cell revealed a striking erythroid bias of all myeloid-competent progenitors assessed, accompanied by strong platelet production that far exceeded generation of myelomonocytic, B and T cells.

Source: Experimental Hematology - August 22, 2017 Category: Hematology Authors: Camilla Forsberg Source Type: research