Single cells undergoing cell fate change during endothelial-to-hematopoietic cell transition show pulsatile Gata2 expression

Underpinning cell behavior during development and differentiation, are fundamental dynamic expression changes that drive cell fate processes away from a pre-existing equilibrium. The Gata2 transcription factor is an important regulator of blood cell differentiation and development, and is pivotal to hematopoietic stem cell generation (HSC). Within a short window of developmental time HSCs originate from a natural differentiation of hemogenic endothelial cells through a process called endothelial to hematopoietic transition (EHT).
Source: Experimental Hematology - Category: Hematology Authors: Source Type: research