Leukemic mesenchymal stromal cell COX2-PG signaling regulates donor anti-leukemia immunity
Hematopoietic stem cell transplantation (HSCT) is considered the gold standard for treatment of hematologic malignancies, including Fanconi anemia (FA), a cancer-prone disease with extremely high incidence of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). However, eradication of residual leukemia stem cells (LSCs), which often contributes to relapse, remains the challenge for HSCT. Here we investigate the interaction between leukemic mesenchymal niche and donor hematopoietic stem progenitor cells (HSPCs) by modeling FA HSCT.
CONCLUSIONS: The incidence of cervical cancer in Jordan is low compared to regional estimates and remained relatively constant between 2008 and 2013. Implementation of screening measures could lead to better case finding, early diagnosis, and prevention of cervical cancer. PMID: 28932241 [PubMed]
ConclusionsIntegrated medical and psychiatric care is needed to improve outcomes of cancer care among patients with SMI. PMID: 28935659 [PubMed - as supplied by publisher]
ZURICH (Reuters) - Roche immunotherapy Tecentriq has won European Union approval for treating advanced lung and bladder cancer, the Swiss drugmaker said.
Purple potatoes and other colorful fruits and vegetables could help to prevent colon cancer by reducing levels of a pro-inflammatory protein.
This study aimed to develop a method for eliciting and coding recall of medical information in non‐English‐speaking patients. DesignThis method, called Patient‐Interpreter‐Clinician coding (PICcode), was developed in the context of a phase II trial conducted in two outpatient oncology clinics in Melbourne, Australia, and was refined iteratively through consultation with an expert panel and piloting. Between‐coder differences in early versions of the coding system were resolved through discussion and consensus resulting in refinements to PICcode. ResultsThe final version of PICcode involved transcribing, translati...
Contributor : Stephanie RoesslerSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiensGallbladder carcinoma (GBC) is a rare cancer entity in Western Europe and the US with an incidence of less than 3/100.000 and a survival rate
Authors: Kolb A, Gibson P, O'Sullivan ED PMID: 28931703 [PubMed - in process]
In this study, we performed recursive partitioning analysis (RPA) to objectively combine the 15-ELN threshold and 8th AJCC stage to refine the staging for GC.MethodsWe analyzed 19,018 patients with non-metastatic GC from the Surveillance, Epidemiology, and End Results database. The dataset was randomly divided into training and validation sets.ResultsFor each 8th AJCC stage, survival was significantly better for patients with ≥15 ELNs versus those with
Authors: Young Son M, Deng CX, Hoeijmarkers JH, Rebel VI, Hasty P Abstract Benzene is a common environmental toxin and its metabolite, 1-4-Benzoquinone (BQ) causes hematopoietic cancers like myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). BQ has not been comprehensively assessed for its impact on genome maintenance, limiting our understanding of the true health risks associated with benzene exposure and our ability to identify people with increased sensitivity to this genotoxin. Here we analyze the impact BQ exposure has on wild type and DNA repair-defective mouse embryonic stem (ES) cells and wild...
Publication date: September–December 2014 Source:Best Practice & Research Clinical Haematology, Volume 27, Issues 3–4 Author(s): Blanche P. Alter Fanconi anemia (FA) is a rare autosomal recessive cancer-prone inherited bone marrow failure syndrome, due to mutations in 16 genes, whose protein products collaborate in a DNA repair pathway. The major complications are aplastic anemia, acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), and specific solid tumors. A severe subset, due to mutations in FANCD1/BRCA2, has a cumulative incidence of cancer of 97% by age 7 years; the cancers are AML, brain ...