Computational Psychiatry: Embracing Uncertainty and Focusing on Individuals, Not Averages

A 55-year-old woman presents seeking treatment with clear symptoms of a major depressive episode. This is her third such episode. She reports that sertraline worked well for her the first time. The second time, however, it made her dizzy and she had to discontinue; she eventually responded well to bupropion. She expresses a preference for medication over psychotherapy but is not sure which one to try. What do you do? Do you try bupropion again? It worked last time, but in exploring her current symptoms it is clear that she has prominent feelings of somatic and psychological anxiety that she did not experience last time.
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Clinical Commentary Source Type: research