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Boy with heart transplant dies on first day of school

Peyton West's parents would never have thought that his first day of school this year was going to be his last.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news

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I am a bookworm. As a child I always wanted to go to the library and didn't mind that if I read my newly selected books on the way home I might start to be a bit woozy from the wiggly New England roads. (Highways are much better for car reading.)In times of stress (read'medical disasters'among other things) I often turn to books as my personal form of avoidance. This was fine until my medical maladies kept interfering with my reading enjoyment. That would really suck.During college, after thyroid cancer, with my small paperback book collection, I would avoid studying or read in bed something less enlightening than any requ...
Source: Caroline's Breast Cancer Blog - Category: Cancer & Oncology Tags: books cancer stigma coping reading Source Type: blogs
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Short-term outcomes of solid organ transplantation have improved dramatically over the past several decades; however, long-term survival has remained static over the same period, and chronic rejection remains a major cause of graft failure. The importance of donor, or “passenger,” lymphocytes to the induction of tolerance to allografts was recognized in the 1990s, but their precise contribution to graft acceptance or rejection has not been elucidated. Recently, specialized populations of tissue-resident lymphocytes in nonlymphoid organs have been described. These lymphocytes include tissue-resident memory T cel...
Source: Transplantation - Category: Transplant Surgery Tags: Reviews Source Type: research
Conclusions Induction with sc28AT promotes early cardiac allograft protection in hu5C8-treated NHPs. These results support further investigation of prolonged selective CD28 inhibition with CD40/CD154 blockade in NHP transplants.
Source: Transplantation - Category: Transplant Surgery Tags: Original Basic Science—General Source Type: research
Conclusions Compared with immediate initiation, delayed everolimus initiation appeared to provide a clinically relevant early safety benefit in de novo HTx recipients, without compromising efficacy.
Source: Transplantation - Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research
Background We hypothesized C1q binding de novo donor-specific antibody (DSA) after heart transplant (HT) is a higher risk for development of coronary artery vasculopathy (CAV) in children. Methods A retrospective analysis of 127 pediatric HT recipients transplanted between January 2005 and December 2014 was used to determine complement (C1q)-binding de novo DSA on the outcomes of HT and the ability of the C1q assay to predict CAV development. Results Of 127 patients, 59 (46.4%) developed de novo DSA, 37 of those had C1q+ DSA. There was no difference in baseline characteristics except patients who developed C1q+ DSA...
Source: Transplantation - Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research
AbstractPurposeCerebral microbleeds (CMBs) are small rounded lesions representing cerebral hemosiderin deposits surrounded by macrophages that results from previous microhemorrhages. The aim of this study was to review the distribution of cerebral microbleeds in patients with end-stage organ failure and their association with specific end-stage organ failure risk factors.Materials and methodsBetween August 2015 and June 2017, we evaluated 15 patients, 9 males, and 6 females, (mean age 65.5  years). Patients population was subdivided into three groups according to the organ failure: (a) chronic kidney failure (n =...
Source: La Radiologia Medica - Category: Radiology Source Type: research
Heart failure results in significant morbidity and mortality for young children with hypoplastic left heart syndrome (HLHS) following the Norwood procedure.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
Incompatibility to HLA antigens was the sentinel barrier which historically limited solid organ transplantation. The development of the complement dependent cytotoxicity (CDC) assay by Terasaki half a century ago allowed estimation of rejection risk at transplantation.1 Subsequent emergence of effective immunosuppressive regimens led to significant expansion of transplantation as a suitable therapeutic option for end-stage organ disease. In heart transplantation, the resulting improvement in outcomes has led to a corresponding broadening of the indications for transplant.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
The optimal strategy for prevention of invasive fungal infections in lung transplant recipients remains undetermined. We studied a bronchoalveolar lavage fungal culture and galactomannan based strategy for prevention of invasive aspergillosis in lung transplant recipients
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
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