Interleukin 6 induces M2 macrophage differentiation by STAT3 activation that correlates with gastric cancer progression

In conclusion, our data indicate that IL-6 induces M2 macrophage differentiation (IL-10highTGF- βhighIL-12p35low) by activating STAT3 phosphorylation, and the IL-6-induced M2 macrophages exert a pro-tumor function by promoting GC cell proliferation and migration.
Source: Cancer Immunology, Immunotherapy - Category: Cancer & Oncology Source Type: research