The association between pre-treatment maternal alcohol and caffeine intake and outcomes of assisted reproduction in a prospectively followed cohort

AbstractSTUDY QUESTIONIs pre-treatment alcohol and caffeine intake associated with infertility treatment outcomes among women undergoing ART?SUMMARY ANSWERLow to moderate alcohol and caffeine intakes in the year prior to infertility treatment were not related to ART outcomes.WHAT IS KNOWN ALREADYAlcohol and caffeine intake have been found to be associated with infertility in some studies. Nevertheless, data on their relation with outcomes of infertility treatments are scarce and inconsistent.STUDY DESIGN, SIZE, DURATIONWe included 300 women (493 ART cycles) from the Environment and Reproductive Health Study, an ongoing cohort study (2006 –2016).PARTICIPANTS/MATERIALS, SETTING, METHODSPre-treatment intakes of alcohol and caffeine were assessed retrospectively using a validated food frequency questionnaire. Intermediate and clinical endpoints of ART were abstracted from electronic medical records. Generalized linear mixed models with random intercepts to account for multiple ART cycles per woman were used to evaluate the association with ART outcomes adjusting for age, BMI, smoking status, infertility diagnosis, protocol type, race, dietary patterns, and calories, vitamin B12 and folate intake.MAIN RESULTS AND THE ROLE OF CHANCEMedian (range) pre-treatment alcohol and caffeine intakes were 5.6 (0.0 –85.8) g/day and 124.9 (0.3–642.2) mg/day, respectively. The adjusted percentage of initiated cycles resulting in live birth (95% CI) for women in increasing categories of pre-...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research