Cdk4 regulates adult neural stem cell proliferation and differentiation in response to insulin ‐IRS2 signals

This article is protected by copyright. All rights reserved. Insulin stimulates proliferation of adult neural stem cells (NSC) to form neurospheres through activation of insulin receptor substrate IRS2 and protein kinase B (PKB/AKT) leading to increased activity of cyclin‐dependent kinase CDK4. Activation of the same pathway mediates the effects of insulin in promoting the differentiation of neurons (in red) and oligodendrocytes (in green) and in neuritogenesis.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1002%2Fstem.2694

Source: Stem Cells - August 20, 2017 Category: Stem Cells Authors: Laura Chirivella, Martina Kirstein, Sacri R. Ferr ón, Ana Domingo‐Muelas, Fabrice C. Durupt, Carlos Acosta‐Umanzor, Marifé Cano‐Jaimez, Francisco Pérez‐Sánchez, Mariano Barbacid, Sagrario Ortega, Deborah Burks, Isabel Fariñas Tags: Tissue ‐Specific Stem Cells Source Type: research

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