Bionic heart patient relies on portable pump in handbag to transfer blood around body
Daniela Vargova, 30, from Chippenham, Wiltshire, was diagnosed with dilated cardiomyopathy following a cardiac arrest and now relies on the life-saving equipment.
Publication date: Available online 17 October 2019Source: Nutrition, Metabolism and Cardiovascular DiseasesAuthor(s): Xiao-lan Chen, Xue-biao Wei, Jie-leng Huang, Zu-hui Ke, Ning Tan, Ji-yan Chen, Yuan-hui Liu, Dan-qing YuAbstractBackground and AimsThe prognostic nutritional index (PNI) had been associated with adverse outcomes in numerous clinical conditions. However, its influence on idiopathic dilated cardiomyopathy (DCM) was not determined. This aim of this study was to determine the predictive ability of PNI in patients with idiopathic DCM.Methods and ResultsA total of 1,021 consecutive patients with idiopathic DCM we...
To recapitulate progressive human dilated cardiomyopathy (DCM) and heart block in the Lmna R225X mutant mice model and investigate the molecular basis of LMNA mutation induced cardiac conduction disorders (CD); To investigate the potential interventional impact of exercise endurance.
We present a retrospective review of 13 consecutive children who underwent implantation of VAD between 2001 and 2018 in our center. The median age was 12 years (1–17 years), weight was 45 kg (10–82 kg). Etiologies of heart failure were dilated cardiomyopathy (CMP) (n = 8), myocarditis (n = 2), ischemic CMP (n = 1), restrictive CMP (n = 1) and congenital heart disease (n = 1). Pre-implantation ECMO was used in 5, mechanical ventilation in 4, renal replacement therapy in 2 and IABP in 1. Devices used were: Berlin Heart EXCO...
The prognostic nutritional index (PNI) had been associated with adverse outcomes in numerous clinical conditions. However, its influence on idiopathic dilated cardiomyopathy (DCM) was not determined. This aim of this study was to determine the predictive ability of PNI in patients with idiopathic DCM.
The indications for mitral valve surgery in patients with advanced non-ischemic dilated cardiomyopathy and functional mitral regurgitation are still unclear. We reviewed our experience of mitral valve surgery in such patients and explored factors that were predictive of outcomes. Fifty-three consecutive patients with non-ischemic dilated cardiomyopathy and an ejection fraction
We present two young patients (
ConclusionsWe describe a unique and novel cellular model that provides insight into the mitochondrial abnormalities present in DCMA and identifies SS-31 as a potential therapeutic for this devastating disease.
Nature Reviews Cardiology, Published online: 11 October 2019; doi:10.1038/s41569-019-0284-0In this Review, Rosenbaum and colleagues give a broad perspective on the genetic causes of dilated cardiomyopathy to provide a context for a discussion of the pragmatic use of genetic testing in heart failure clinics for patients presenting with new-onset dilated cardiomyopathy.
The time course for hemodynamic normalization after pediatric heart transplantation (HTx) has not been well characterized. We hypothesized that single ventricle patients would normalize later than those with dilated cardiomyopathy (DCM). Establishing the expected course based on the underlying pathophysiology will allow identification of patients who are outliers requiring further investigation.
Publication date: Available online 8 October 2019Source: Best Practice &Research Clinical Obstetrics &GynaecologyAuthor(s): Benjamin Wainwright, Rohit Bhan, Catherine Trad, Rebecca Cohen, Amit Saxena, Jill Buyon, Peter IzmirlyAbstractAutoimmune-mediated congenital heart block (CHB) is a severe manifestation of neonatal lupus in which conduction tissues of the fetal heart are damaged. This occurs due to passive transference of maternal Ro (SSA) and La (SSB) autoantibodies, and subsequent inflammation and fibrosis of the atrioventricular (AV) node. Notably, the disease manifests after the fetal heart has structurally...