An infant with acute gastroenteritis caused by a secondary infection with a Rotarix-derived strain

Conclusion: This is a severe acute gastroenteritis case most probably attributed to the secondary infection of Rotarix-related virus without underlying diseases. The importance of molecular surveillance of rotavirus infections is discussed.What is Known:•The live-attenuated rotavirus vaccines, Rotarix and RotaTeq, have been successful in controlling severe diarrhea and have decreased deaths of young children globally.•Attenuated vaccine virus can grow in a recipient ’s gut and spread to naïve individuals and may revert to cause secondary symptomatic infections.What is New:•This is the first report describing a Rotarix-associated secondary infection resulting in severe acute gastroenteritis in an infant without underlying diseases.•Amino acid mutations that might contribute to viral pathogenesis were identified by whole genome sequencing.
Source: European Journal of Pediatrics - Category: Pediatrics Source Type: research