Elevated Immune Response Among Children 4 Years of Age With Pronounced Local Adverse Events After the Fifth Diphtheria, Tetanus, Acellular Pertussis Vaccination

Conclusions: Children with pronounced local reactions show higher humoral and cellular immune responses. Acellular vaccines are known to skew toward more Th2 responses. The pronounced local AEs may be associated with more Th2 skewing after the fifth DTaP-IPV vaccination, but other biologic factors may also impact the occurrence of these pronounced local reactions.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Vaccine Reports Source Type: research

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Infectious diseases, such as diphtheria, pertussis, tetanus, Haemophilus influenzae type B, and poliomyelitis (polio), are seriously harmful to children's health. Vaccination is the most effective way to control these diseases. In 2010, the State Food and Drug Administration approved the DTaP-IPV/Hib combination vaccine (from now on referred to as the pentavalent vaccine) for cell-free pertussis (DTaP), inactivated poliomyelitis and Haemophilus influenzae type B (combination), and children started to be vaccinated with this pentavalent vaccine on May 11, 2011, in China.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
Condition:   Meningococcal Infection (Healthy Volunteers) Interventions:   Biological: Meningococcal Polysaccharide (Serogroups A, C, Y, and W) Tetanus Toxoid Conjugate Vaccine MenACYW conjugate vaccine;   Biological: Meningococcal group A, C, W-135, and Y conjugate vaccine;   Biological: Human Papillomavirus 9-valent Vaccine 9vHPV;   Biological: Tetanus Toxoid, Red uced Diphtheria Toxoid and Acellular Pertussis Vaccine Adsorbed Combined with Inactivated Poliomyelitis Vaccine Tdap-IPV Sponsor:   Sanofi Pasteur, a Sanofi Company Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
The objectives of this study were to assess the immunization coverage of children aged 5-6 years and 13-14 years during the 2017-2018 school year, and to identify sociodemographic factors associated with full immunization in these children. MATERIALS AND METHODS: A descriptive cross-sectional school-based study was carried out. The population under study was a sample of schoolchildren aged 5-6 years and 13-14 years attending the second and 10th grades of primary and middle schools, respectively, located in the canton of Geneva, Switzerland. The data extracted from the vaccination cards included dates of administration...
Source: Archives de Pediatrie - Category: Pediatrics Authors: Tags: Arch Pediatr Source Type: research
Background: Iron deficiency may impair adaptive immunity and is common among African infants at time of vaccination. Whether iron deficiency impairs vaccine response and whether iron supplementation improves humoral vaccine response is uncertain.Methods: We performed two studies in southern coastal Kenya. In a birth cohort study, we followed infants to age 18 mo and assessed whether anemia or iron deficiency at time of vaccination predicted vaccine response to three-valent oral polio, diphtheria-tetanus-whole cell pertussis-Haemophilus influenzae type b vaccine, ten-valent pneumococcal-conjugate vaccine and measles vaccine...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Conditions:   Pertussis Immunisation;   Diphtheria Immunisation;   Polio Immunisation;   Hepatitis B Immunisation;   Haemophilus Influenzae Type B Immunisation;   Tetanus Immunisation;   Rotavirus Immunisation;   Pneumococcal Immunisation Interventions:   Biological: DTwP-HepB-Hib-IPV hexavalent vaccine (Diphtheria toxoid, Tetanus toxoid, whole cell pertussis, Hepatitis B surface antigen (HBsAg), Haemophilus influenzae type b, inactivated poliovirus);   Biological: DTwP-HepB-Hib pentavalent vaccine (Diphtheria toxo...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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