The cardiovascular toxicity of triadimefon in early life stage of zebrafish and potential implications to human health.

The cardiovascular toxicity of triadimefon in early life stage of zebrafish and potential implications to human health. Environ Pollut. 2017 Aug 10;: Authors: Liu HC, Chu TY, Chen LL, Gui WJ, Zhu GN Abstract The health risk of triadimefon (TF) to cardiovascular system of human is still unclear, especially to pesticide suicides population, occupational population (farmers, retailers and pharmaceutical workers), and special population (young children and infants, pregnant women, older people, and those with compromised immune systems) who are at a greater risk. Therefore, firstly we explored the toxic effects and possible mechanism of cardiovascular toxicity induced by TF using zebrafish model. Zebrafish at stage of 48 h post fertilization (hpf) exposed to TF for 24 h exhibited morphological malformations which were further confirmed by histopathologic examination, including pericardial edema, circulation abnormalities, serious venous thrombosis and increased distance between the sinus venosus (SV) and bulbus arteriosus (BA) regions of the heart. In addition to morphological changes, TF induced functional deficits in the heart of zebrafish, including bradycardia and a significant reduced cardiac output that became more serious at higher concentrations. To better understand the possible molecular mechanisms underlying cardiovascular toxicity in zebrafish, we investigated the transcriptional level of genes related to calcium signaling ...
Source: Environmental Pollution - Category: Environmental Health Authors: Tags: Environ Pollut Source Type: research