Hormonal control of metabolism: regulation of plasma glucose

Publication date: Available online 15 August 2017 Source:Anaesthesia & Intensive Care Medicine Author(s): Niroshini Nirmalan, Mahesh Nirmalan Blood glucose concentrations are required to be maintained within a narrow therapeutic range in order to ensure the normal functioning of the body. This is accomplished through a complex, interactive, finely coordinated neuro-endocrine regulatory process. Hormonal control through the opposing actions of insulin and glucagon secreted by the islet cells of the pancreas serve as the primary response mechanism to avert post-prandial hyperglycaemia and fasting hypoglycaemia. In addition to this basic response, a range of endocrine mediators concurrently intervene, to enable the fine modulation of the process through a range of insulin-dependent and insulin-independent processes, which ultimately achieve glycaemic control by influencing tissue glucose uptake, glycolysis, glycogenesis, glycogenolysis and gluconeogenesis. More recent evidence supports a central, predominantly hypothalamic role initiated through nutrient (glucose, fatty acid) and hormonal (insulin, leptin, glucagon-like peptide-1) stimuli that influences glucose regulation by direct or indirect effects on skeletal muscle glucose uptake, islet cell insulin/glucagon secretion and hepatic glucose production.
Source: Anaesthesia and intensive care medicine - Category: Anesthesiology Source Type: research

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The objective of this paper was to present a clinical case of ceramic veneers and crowns in which a retraction paste was used for gingival displacement during both the impression and cementation stages, with 3 years of follow-up. Treatment planning consisted of the replacement of preexisting crowns and ceramic veneers on the anterior teeth. After finishing the preparations, gingival displacement with Astringent Retraction Paste was performed without anesthesia or the use of cords and the impression was taken. Before cementation of the crowns and veneers, the Astringent Retraction Paste was applied. Avoiding the use of cord...
Source: Quintessence International - Category: Dentistry Source Type: research
Publication date: Available online 18 August 2019Source: Journal of Oral Biology and Craniofacial ResearchAuthor(s): Sourav Sarkar, N.T. Prashanth, E.S. Shobha, Vinod Rangan, G. NikhilaAbstractObjectivesThe aim of this study is to compare the effectiveness of Platelet Rich Fibrin gel and Chitosan gel dressing in providing hemostasis in patients receiving Oral Antiplatelet Therapy and also to evaluate their surgical healing outcome following dental extractions.MethodologyA total of 60 patients under Oral Antiplatelet Therapy indicated for tooth extraction were included for treatment in the study without altering the oral an...
Source: Journal of Oral Biology and Craniofacial Research - Category: Dentistry Source Type: research
Question for the inventors of SDN: I have an idea for a medical device. It’s relatively simple, and I think it would have significant commercial value... That being said, I have virtually no experience with fabrication, biomedical engineering, patent law, etc. Anyone have any relevant experience or advice? To those who have applied for patents, any tips on the process? Worth it to get a patent lawyer, or is it something I can navigate myself and save a few grand? I do work for an academic... Medical Device
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Anesthesiology Source Type: forums
In this study, anesthesia/surgery impaired cognition, demonstrated by an increase escape latency and reduction in the number of platform crossings in Morris water maze (MWM) trials, through activating microglia neuroinflammation and decreasing PSD-95 expression. However, pretreatment with MS-275 attenuated postoperative cognitive impairment severity. Furthermore, pretreatment with MS-275 decreased activated microglia levels and increased PSD95 protein expression in the hippocampus. Pretreatment with MS-275 reduced NF-κB-p65 protein expression and nuclear accumulation as well as the neuroinflammatory response (product...
Source: Neuroscience - Category: Neuroscience Source Type: research
AbstractAn adult male jungle cat (Felis chaus) weighing 6  kg with the history of inability to bearing weight on its left forelimb was presented. Physical examination and radiography revealed transverse radio-ulna fracture and carpal subluxation. Internal fixation with plate was chosen for treatment. On the day of surgery, anesthesia was induced with intr amuscular ketamine (10 mg/kg) and midazolam (0.3 mg/kg). Brachial plexus block (BPB) was performed using lidocaine (3 mg/kg) and bupivacaine (0.75 mg/kg) mixture guided by an electrical nerve stimulator. During the surgery, anesthesia was maintain...
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research
ConclusionThe nontourniquet combined with controlled hypotension technique can alleviate chronic pain and promote the long-term rehabilitation of patients after TKA.
Source: Journal of Anesthesia - Category: Anesthesiology Source Type: research
Publication date: Available online 17 August 2019Source: Anaesthesia &Intensive Care MedicineAuthor(s): Claire E. Adams, Michael DobsonAbstractThere is a discrepancy between healthcare need and the ability to provide safe anaesthesia in low/low-middle income countries (LMICs). There is a shortage of medically trained anaesthetists. Most anaesthetics are provided by non-physician anaesthetists who may not have studied the core sciences underpinning anaesthesia, but are clinically very competent. Poor infrastructure is common, such as a shortage of piped medical gases and critical care beds. Safe anaesthesia depends on e...
Source: Anaesthesia and intensive care medicine - Category: Anesthesiology Source Type: research
Chairman of UA's anesthesiology department steps down over leadership concerns Dr. Randal Dull will remain as tenured professor and physician at the UA. tucson.com
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Anesthesiology Source Type: forums
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Source: Best Practice and Research Clinical Anaesthesiology - Category: Anesthesiology Source Type: research
This article describes challenges through reflection on personal experience in Zambia.
Source: Anaesthesia and intensive care medicine - Category: Anesthesiology Source Type: research
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